Multiomics After Headache Provocation of People Who Are Unable to Have Headache
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- STATUS
- Recruiting
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- participants needed
- 60
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- sponsor
- Danish Headache Center
Summary
Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache.
The aim of the study is to identify factors that protect against headache by studying multiomics in people who never have had a headache (headache resistant) versus non-resistant controls.
The investigators will measure multiomic changes (transcriptomics and metabolomics) after headache provocation with isosorbide mononitrate. 3 blood samples, two for RNA and one for metabolomics are taken right before administration of isosorbide mononitrate, 3 hours after administration of isosorbide mononitrate and again 5 hours after administration of isosorbide mononitrate.
The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.
Details
| Condition | Headache, Pain, Pain, Healthy |
|---|---|
| Age | 18years - 70years |
| Treatment | Blood sample, Isosorbide Mononitrate 60 MG Extended Release Oral Tablet [Imdur] |
| Clinical Study Identifier | NCT04218760 |
| Sponsor | Danish Headache Center |
| Last Modified on | 19 February 2024 |
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