FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma
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- STATUS
- Recruiting
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- End date
- Jan 1, 2026
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- participants needed
- 538
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- sponsor
- Blokhin's Russian Cancer Research Center
Summary
Patients with resectable adenocarcinoma of the stomach or the esophagogastric junction (II-III type by Siewert) without previous therapy will be treated with one of two chemotherapy combinations before and after surgery. One half of the patients gets 5-Fluorouracil (5-FU), Leucovorin, Oxaliplatin and Docetaxel (FLOT), the others 5-Fluorouracil (5-FU), Leucovorin, Oxaliplatin and Irinotecan (FOLFIRINOX). Main objective of the study is median overall survival.
Description
538 Patients with resectable (cT4cN0 or cT1-4 and cN+, cM0) adenocarcinoma of the stomach or the esophagogastric junction without previous therapy will be included in this study. After randomization patients receive perioperatively 4 cycles FLOT or FOLFIRINOX, followed by a restaging of the tumour status and surgery. Subsequently another 4 cycles of FLOT or FOLFIRNOX are applicated.
Details
| Condition | Fluorouracil, Gastrointestinal Neoplasm, GASTROINTESTINAL DISORDER, Neoplasm of unspecified nature of digestive system, Gastropathy, stomach discomfort, Gastric Cancer, Gastric Cancer, stomach cancer, stomach cancer, stomach discomfort, Docetaxel, Oxaliplatin, Irinotecan Hydrochloride |
|---|---|
| Age | 18-70 years |
| Treatment | Irinotecan, Oxaliplatin, 5-FU, Leucovorin, Docetaxel |
| Clinical Study Identifier | NCT04393584 |
| Sponsor | Blokhin's Russian Cancer Research Center |
| Last Modified on | 19 February 2024 |
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