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Found 5 clinical trials
Multimodality Treatment in Stage III Non-small Cell Lung Cancer (NSCLC)

The aim of the proposed SAKK 16/18 trial is to evaluate the efficacy and safety of adding immune-modulatory radiotherapy to the SAKK 16/14 treatment regimen by combining neo-adjuvant radio-immunotherapy. Due to the lack of evidence for an optimal radiotherapy regimen for an "in-situ vaccination" effect three different radiotherapy regimens will …

measurable disease
adjuvant therapy
ct scan with contrast
blood transfusion
large cell carcinoma
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  • 19 Feb, 2024
Hypofractionated Radiotherapy in Elderly Patients With Head & Neck Squamous Cell Carcinoma

The purpose of this research study is to investigate a shorter radiation treatment schedule for head and neck cancers in patients 70 years of age and older. Standard radiation treatment for head and neck patients normally requires that the patient travel to the hospital daily for 6-7 weeks to receive …

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  • 19 Feb, 2024
Personalized Extended Interval Dosing of Natalizumab in Relapsing Remitting Multiple Sclerosis

Rationale: Natalizumab is an effective drug in the treatment for relapsing remitting multiple sclerosis (RRMS) and is approved in the treatment regimen of 4-weekly 300mg natalizumab infusions. Natalizumab trough concentrations after a 4-weekly interval are high in the large majority of patients which implies a relative overdose in most patients.

multiple sclerosis
natalizumab
white matter disease
progressive multifocal leukoencephalopathy
relapsing multiple sclerosis
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  • 19 Feb, 2024
Concurrent Chemoradiotherapy After Endoscopic Resection for Stage I Esophageal Carcinoma

This is a prospective single-arm study of endoscopic resection (ER) following concurrent chemoradiotherapy for stage I esophageal squamous cell carcinoma, to find if the treatment combination is useful by assessing its safety and efficacy.

blood pregnancy test
metastasis
mucous membrane
esophageal carcinoma
endoscopic resection
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  • 19 Feb, 2024
A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health

This is a 48-month observational, prospective, multicentre study. The overall aim of the study is to evaluate the long-term effectiveness of Elocta treatment on joint health in patients treated prophylactically with Elocta in a real-world setting.

antihemophilic factor
hemophilia
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  • 19 Feb, 2024