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Found 5 clinical trials
Multimodality Treatment in Stage III Non-small Cell Lung Cancer (NSCLC)

The aim of the proposed SAKK 16/18 trial is to evaluate the efficacy and safety of adding immune-modulatory radiotherapy to the SAKK 16/14 treatment regimen by combining neo-adjuvant radio-immunotherapy. Due to the lack of evidence for an optimal radiotherapy regimen for an "in-situ vaccination" effect three different radiotherapy regimens will …

large cell carcinoma
pneumonectomy
immunomodulators
vaccination
non-small cell lung cancer
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  • 19 Feb, 2024
Hypofractionated Radiotherapy in Elderly Patients With Head & Neck Squamous Cell Carcinoma

The purpose of this research study is to investigate a shorter radiation treatment schedule for head and neck cancers in patients 70 years of age and older. Standard radiation treatment for head and neck patients normally requires that the patient travel to the hospital daily for 6-7 weeks to receive …

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  • 19 Feb, 2024
Personalized Extended Interval Dosing of Natalizumab in Relapsing Remitting Multiple Sclerosis

Rationale: Natalizumab is an effective drug in the treatment for relapsing remitting multiple sclerosis (RRMS) and is approved in the treatment regimen of 4-weekly 300mg natalizumab infusions. Natalizumab trough concentrations after a 4-weekly interval are high in the large majority of patients which implies a relative overdose in most patients.

multiple sclerosis
relapsing multiple sclerosis
extended interval dosing
white matter disease
progressive multifocal leukoencephalopathy
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  • 19 Feb, 2024
Concurrent Chemoradiotherapy After Endoscopic Resection for Stage I Esophageal Carcinoma

This is a prospective single-arm study of endoscopic resection (ER) following concurrent chemoradiotherapy for stage I esophageal squamous cell carcinoma, to find if the treatment combination is useful by assessing its safety and efficacy.

squamous cell carcinoma of esophagus
endoscopic resection
blood pregnancy test
chemoradiotherapy
esophageal squamous cell carcinoma
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  • 19 Feb, 2024
A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health

This is a 48-month observational, prospective, multicentre study. The overall aim of the study is to evaluate the long-term effectiveness of Elocta treatment on joint health in patients treated prophylactically with Elocta in a real-world setting.

hemophilia
antihemophilic factor
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  • 19 Feb, 2024