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Found 3 clinical trials
Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients

This is an open label, single arm, multicenter, phase Ib study to evaluate the safety and clinical activity of the combination of ipatasertib, trastuzumab and pertuzumab in patients with unresectable locally advanced or metastatic HER2-positive breast cancer with tumors harboring PIK3CA mutations, candidates to receive maintenance HP after first line …

invasive breast cancer
ejection fraction
her2/neu-positive breast cancer
immunological adjuvant
taxane
  • 0 views
  • 19 Feb, 2024
  • 10 locations
Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer

The BREAKFAST trial will evaluate the antitumor activity of combining cyclic fasting-mimicking diet (FMD), which reproduces the in vitro effects of glucose starvation, plus/minus metformin with standard preperative anthracycline-taxane chemotherapy in patients with stage I-III TNBC

taxane
oophorectomy
anthracycline
anthracyclines
direct bilirubin
  • 0 views
  • 19 Feb, 2024
  • 1 location
Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Cancer.

The objective of this trial is to study the efficacy of treatment of human papilloma virus (HPV) related oropharyngeal cancer with chemotherapy followed by Transoral Robotic Surgery (TORS) as definitive treatment. Current treatment of oropharyngeal cancer are chemo-radiotherapy. There is significant lifelong side effects associated with this approach related to …

definitive treatment
metastasis
carcinoma
chemo-radiotherapy
primary tumor
  • 0 views
  • 19 Feb, 2024
  • 1 location