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Found 2 clinical trials
Study to Evaluate the Pharmacokinetics (PK) of E7090 and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants
The primary purpose of the study is to evaluate the effects of mild and moderate hepatic impairment on PK of E7090 after a single dose administration.
moderate hepatic impairment
electrocardiogram
e7090
electrocardiogram (ecg)
body mass index
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- 19 Feb, 2024
- 3 locations
The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics
This is a prospective, single-center, open-label, single-dose, Phase 1 study, to assess the effect of moderate hepatic impairment due to liver cirrhosis on the pharmacokinetics of aprocitentan (ACT-132577).
systolic blood pressure
moderate hepatic impairment
oophorectomy
follicle stimulating hormone
serum pregnancy test
- 0 views
- 19 Feb, 2024
- 1 location