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Found 2 clinical trials
MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma
The proposed study is a two-step trial with 1) a safety run in part conducted in pediatric patients and 2) a Phase II part in adult and pediatric patients aiming to evaluate the safety and clinical activity of atezolizumab + cobimetinib in advanced/metastatic soft tissue sarcomas.
atezolizumab
neutrophil count
screening procedures
aptt
serum pregnancy test
- 0 views
- 19 Feb, 2024
- 4 locations
JSI-1187-01 Monotherapy and in Combination With Dabrafenib for Advanced Solid Tumors With MAPK Pathway Mutations
This is a Phase 1 study of JSI-1187 as monotherapy and in combination with dabrafenib for the treatment of advanced solid tumors with MAPK pathway mutations, including mutations that cause MAPK pathway hyperactivation.
metastatic malignant solid tumor
solid neoplasm
neutrophil count
brain metastases
dabrafenib
- 0 views
- 19 Feb, 2024
- 4 locations