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Study Overview Study Details Eligibility Trial Primary Objective:
To evaluate the effect of dupilumab on sleep quality in adult patients with moderate to severe atopic dermatitis (AD)
Secondary Objectives:
To evaluate the effect of dupilumab on objective and subjective quantitative sleep parameters, AD related outcomes, and daytime consequences of sleep deprivation
To continue to …

  • 0 views
  • 19 Feb, 2024
Featured trial
Study on the Visual Condition in Parkinson's Disease  

Non motor symptoms and signs in Parkinson's disease (PD) also include a series of visual deficits; deepening these aspects could be useful for a better management of symptoms, to standardize a specific protocol for the issues related to vision and also to understand how these aspects are important for the …

parkinson's disease
motor symptoms
  • 0 views
  • 19 Feb, 2024
  • 2 locations
SAR408701 Versus Docetaxel in Previously Treated Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small Cell Lung Cancer Patients  

  • The primary objective is to determine whether SAR408701 improves the overall survival (OS) when compared with docetaxel in participants with metastatic non-squamous NSCLC expressing CEACAM5 2+ in intensity in at least 50% of the tumor cell population and previously treated with standard-of-care platinum-based chemotherapy and an immune checkpoint inhibitor.
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    non-small cell lung cancer
    immune checkpoint inhibitor
    squamous nsclc (non-small cell lung cancer)
    pulmonary metastasis
    metastasis
    • 0 views
    • 19 Feb, 2024
    • 52 locations
    A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer

    Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during induction phase:-

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  • Arm A: Tiragolumab plus atezolizumab and CE
  • Arm B: Placebo plus atezolizumab and CE
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    Following the induction phase, participants will continue maintenance therapy with either atezolizumab …

    solid neoplasm
    solid tumour
    carboplatin
    extensive stage sclc
    etoposide
    • 0 views
    • 19 Feb, 2024
    Determination of the Optimal Treatment Target in Ulcerative Colitis

    Participants with active UC will be randomized in a 2:3:5 ratio to 1 of 3 groups, each with a different treatment target. Treatment targets will be defined as:

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  • Group 1: corticosteroid-free symptomatic remission
  • Group 2: corticosteroid-free endoscopic + symptomatic remission
  • Group 3: corticosteroid-free histological + endoscopic …

    ulcerative colitis
    hematochezia
    colitis
    corticosteroids
    remission
    • 0 views
    • 19 Feb, 2024
    A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)

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    hodgkin's disease
    follicular lymphoma
    marginal zone lymphoma
    lymphoma
    malt
    • 0 views
    • 19 Feb, 2024
    SAR439859 Plus Palbociclib as First Line Therapy for Patients With ER(+) HER2(-) Advanced Breast Cancer

    Primary Objective:

    To determine whether SAR439859 in combination with palbociclib improves progression free survival (PFS) when compared with letrozole in combination with palbociclib in participants with ER+, HER2- advanced breast cancer who have not received any prior systemic anticancer therapies for advanced disease.

    Secondary Objective:

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  • To compare …

    HER2
    solid tumour
    her2-negative breast cancer
    goserelin
    metastasis
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    • 19 Feb, 2024
    • 5 locations
    Phase 2 Study of SAR439859 Versus Physician's Choice in Locally Advanced or Metastatic ER-positive Breast Cancer (AMEERA-3)

  • To compare the overall safety profile in the 2 treatment arms.
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    HER2
    stage iv breast cancer
    cancer metastatic
    fulvestrant
    estrogen receptor-positive breast cancer
    • 0 views
    • 19 Feb, 2024
    • 126 locations
    Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis (FREVIVA)

  • The number of scheduled visits will be up to 27 (including 3 follow-up visits) with a visit frequency of every month for the first 6 months and then every 3 months.
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    • 0 views
    • 07 Aug, 2024
    A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

  • To evaluate the effect of venglustat on the lens by ophthalmological examination (Stages 1 and 2).
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    treatment regimen
    fatigue
    glomerular filtration rate
    renal function
    polycystic kidney disease
    • 0 views
    • 19 Feb, 2024
    • 81 locations