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Found 3 clinical trials
Study of Single-dose DS-3201b in Participants With Hepatic Impairment

This is a Phase 1, open-label, parallel design, single-dose pharmacokinetic (PK) study to assess the safety, tolerability, and PK of a single dose of 50 mg of DS-3201b in participants with normal and impaired hepatic function.

estimated creatinine clearance
follicle stimulating hormone
ct scan
moderate hepatic insufficiency
tubal ligation
  • 0 views
  • 19 Feb, 2024
Study to Evaluate the Pharmacokinetics (PK) of E7090 and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants

The primary purpose of the study is to evaluate the effects of mild and moderate hepatic impairment on PK of E7090 after a single dose administration.

e7090
hepatic impairment
electrocardiogram (ecg)
moderate hepatic impairment
moderate hepatic insufficiency
  • 0 views
  • 19 Feb, 2024
The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics

This is a prospective, single-center, open-label, single-dose, Phase 1 study, to assess the effect of moderate hepatic impairment due to liver cirrhosis on the pharmacokinetics of aprocitentan (ACT-132577).

follicle stimulating hormone
oophorectomy
renal function
diastolic blood pressure
moderate hepatic insufficiency
  • 0 views
  • 19 Feb, 2024