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Found 3 clinical trials
Study of Single-dose DS-3201b in Participants With Hepatic Impairment

This is a Phase 1, open-label, parallel design, single-dose pharmacokinetic (PK) study to assess the safety, tolerability, and PK of a single dose of 50 mg of DS-3201b in participants with normal and impaired hepatic function.

moderate hepatic insufficiency
hepatic impairment
hormonal contraception
cervical cap
oral contraceptives
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  • 19 Feb, 2024
Study to Evaluate the Pharmacokinetics (PK) of E7090 and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants

The primary purpose of the study is to evaluate the effects of mild and moderate hepatic impairment on PK of E7090 after a single dose administration.

moderate hepatic insufficiency
moderate hepatic impairment
body mass index
hepatic impairment
electrocardiogram
  • 0 views
  • 19 Feb, 2024
The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics

This is a prospective, single-center, open-label, single-dose, Phase 1 study, to assess the effect of moderate hepatic impairment due to liver cirrhosis on the pharmacokinetics of aprocitentan (ACT-132577).

cirrhosis
oophorectomy
moderate hepatic insufficiency
hepatic impairment
ovarian failure
  • 0 views
  • 19 Feb, 2024