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Found 5 clinical trials
A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)

A phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 in participants at risk for or with frontotemporal dementia due to heterozygous mutations in the progranulin gene.

dementia
progranulin
aphasia
pick's disease
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  • 19 Feb, 2024
Initial Attack on Latent Metastasis Using TAS-102 for ct DNA Identified Colorectal Cancer Patients After Curative Resection

This trial is a randomized, double-blind, multinational Phase III study to evaluate the efficacy and safety of preemptive treatment with FTD/TPI compared with administration of placebo as follow-up, which is the standard of care, in patients who underwent curative resection of colorectal cancer and then tested positive for ctDNA.

ct scan
adenocarcinoma
colorectal cancer
colon cancer
platelet count
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  • 19 Feb, 2024
PET Imaging of Cyclooxygenases in Dementia

Background About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective To learn if two new radiolabeled drugs, [11C]PS13 …

dementia
huntington's disease
neurological examination
cognitive impairment
huntington's chorea
  • 0 views
  • 19 Feb, 2024
Neurodegenerative Diseases Registry

Similarly, distinguishing AD from other dementia syndromes including frontotemporal dementia (FTD), dementia with Lewy Bodies (DLB), corticobasal degeneration (CBD) and vascular dementia can be difficult. It is necessary to develop accurate and comprehensive diagnostic tests to properly prognosticate the diseases, start treatments in early stage of the diseases and maximize …

neurodegenerative disorder
motor neuron disease
supranuclear palsy
vascular dementia
drug trials
  • 0 views
  • 19 Feb, 2024
Feasibility of Passive Data Collection in Dementia Subjects With Agitation

This is a multi-center, observational, feasibility study, to evaluate long term passive data collection, data quality, and user experience of HealthMode Agitation (Apps) to collect motion, location, physiological, and audio data; and eCOA and EMA responses with mobile devices (iPhone, Apple Watch). The purpose of this study is to evaluate …

dementia
agitation
functional activities
  • 0 views
  • 19 Feb, 2024