Found 13 clinical trials
A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
The purpose of this study is to test whether two investigational drugs called CAD106 and CNP520, administered separately, can slow down the onset and progression of clinical symptoms associated with Alzheimer's disease (AD) in participants at the risk to develop clinical symptoms based on their age and genotype.
- 32 views
- 20 Sep, 2024
- 127 locations
Do We Need to Taper Down Steroid Therapy for Bell's Palsy
The objective of our study is to determine the effectiveness and safety of prednisone treatment with no tapering down for Bell's Palsy.
- 0 views
- 19 Feb, 2024
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag
They will visit NIH 6 months after treatment ends. If participants blood counts go down after treatment ends, they may restart the drug....
- 0 views
- 19 Feb, 2024
Tofacitinib for Immune Skin Conditions in Down Syndrome
People with Down syndrome (DS) display widespread immune dysregulation, including several immune skin conditions. This study hypothesizes that pharmacological inhibition of the increased interferon (IFN) signaling seen in DS is safe and could improve associated skin conditions.
- 0 views
- 19 Feb, 2024
Magnetic Resonance Imaging of the Brain and Stomach in Healthy Volunteers and Gastroparesis
The study is to lay the groundwork for non invasive imaging of the GI tract and the brain gut interaction
- 0 views
- 19 Feb, 2024
Doxapram Therapy in Preterm Infants (DOXA Trial)
Preterm infants often suffer from apnea of prematurity (AOP; a cessation of breathing) due to immaturity of the respiratory system. AOP can lead to oxygen shortage and a low heart rate which might harm the development of the newborn, especially the central nervous system. In order to prevent oxygen shortage, …
- 0 views
- 19 Feb, 2024
Genome Environment Microbiome and Metabolome in Autism Study
GEMMA is a multicenter longitudinal observational study that follows children who are genetically at-risk of developing autism for their first three years of life, seeking to identify potential biomarkers predictive of autism development in the blood, stool, urine and saliva. The biomarkers identified in this project will contribute to a …
- 0 views
- 19 Feb, 2024
Intestinal Flora Research Plan for Critically Ill Patients
The gut provides the microbiome with habitat and the nutrients it needs, down-regulates the immune response to form immune tolerance, and promotes its colonization in the intestine.Under physiological conditions, the mutually beneficial symbiosis of the intestine and microorganisms promotes the body's homeostasis.
- 0 views
- 19 Feb, 2024
Aortic Dissection With 4-dimensional Phase-contrast Magnetic Resonance Imaging
We prospectively collected information on consecutive patients who had been evaluated using 4D PC-MRI for aortic pathology in a tertiary hospital between April 2018 and Feb 2020. Patients were eligible for inclusion in the study if they had a clinical indication for CTA of aortic dissections.
- 0 views
- 19 Feb, 2024
Correlation Between Specific Gene Mutationand Local Immune Microenvironment and Immunotherapy Efficacy in NSCLC
Immunotherapy for PD-L1 positive patients is still ineffective in some patientswhich may be related to the complex immune microenvironment.In view of this bottleneck, further refinement of immunotyping and in-depth study of drug resistance mechanism are the most important tasks. In this observational study, we evaluated the difference of gene mutation …
- 0 views
- 19 Feb, 2024
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