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Found 3 clinical trials
Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

This early phase I trial studies the feasibility of giving memantine for the reduction of cognitive impairment after radiation therapy in pediatric patients with central nervous system tumors. Memantine may reduce the effects of radiation therapy on memory and thinking.

central nervous system tumors
cognitive impairment
effects of radiation therapy
memantine
direct bilirubin
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  • 19 Feb, 2024
Tipifarnib for the Treatment of Advanced Solid Tumors Lymphoma or Histiocytic Disorders With HRAS Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have HRAS genetic alterations. Tipifarnib may block the growth of cancer cells that have specific genetic changes in …

refractory ependymoma
percutaneous endoscopic gastrostomy
radiopharmaceutical therapy
cytotoxic chemotherapy
recurrent melanoma
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  • 19 Feb, 2024
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

The blood brain barrier (BBB) prevents some drugs from successfully reaching the target source. Convection-Enhanced Delivery (CED) is a method of direct infusion of drugs under controlled pressure to the tumor that may reduce systemic side effects of drugs in the patient. The purpose of this Phase I study is …

glioma
thromboplastin
coagulation disorder
serum pregnancy test
karnofsky performance status
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  • 19 Feb, 2024