Found 8 clinical trials
Efficacy and Safety of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
This clinical trial is designed to evaluate the efficacy and safety of the combination therapy of SP-8203 (Otaplimastat) and recombinant tissue Plasminogen Activator (rtPA) standard of care. In this clinical trial, rtPA will be injected intravenously using an infusion device. If reperfusion is not occur in spite of rtPA therapy, …
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- 19 Feb, 2024
- 1 location
Effectiveness of a Mobile Neurofeedback for ADHD Youth
Prior to the implementation of the intervention, we conduct a survey with demographic information, behavioral characteristics, clinical global impression, neuropsychological test, brain MRI, NIRS and EEG. The drug naive subjects are randomly assigned to the mobile Neurofeedback group or Sham control group.
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- 19 Feb, 2024
- 1 location
PET Imaging of Cyclooxygenases in Dementia
Background About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective To learn if two new radiolabeled drugs, [11C]PS13 …
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- 19 Feb, 2024
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Minocycline in MS: Confirmation of Benefit
This is an open-label, single-arm clinical trial. Trial participants will include men and women, aged 18-60 years who have had a first demyelinating event within the previous 180 days and who have brain magnetic resonance imaging (MRI) with at least two brain T2 lesions which are at least 3 mm …
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- 19 Feb, 2024
- 1 location
Epidemiologic and Clinical Characteristics of Optic Neuritis in China
This will be a hospital-based retrospective multi-center study on epidemiologic and clinical characteristics of optic neuritis among Chinese. The investigation will cover about 29 provinces or municipalities all around China.
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- 19 Feb, 2024
- 1 location
Better Delineation of YY1 Related Phenotype and Epigenetic Signatures.
The aims of this study are first to better delineate the clinical phenotype, as well as the neuropsychological profile, and the brain MRI characteristics; and, second, to study the epigenetic signatures in a cohort of individuals with YY1 intragenic pathogenic variants.
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- 19 Feb, 2024
- 1 location
Neurodegenerative Diseases Registry
With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian syndromes (PS), small vessel disease (SVD) and motor neuron disease (MND). In spite of the progress of knowing the pathogenesis …
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- 19 Feb, 2024
- 1 location
Brain MRI in Stroke Patients With Intracardiac Thrombus
In earlier reports, infarction of cardioembolic origin has been associated with acute lesions involving the cortex, and with multiple acute lesions in single or multiple cerebral circulation territories, and small (most often chronic and asymptomatic) cortical cerebellar infarctions (SCCI). Our aim was to analyse brain MRI characteristics in patients presenting …
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- 19 Feb, 2024
- 1 location