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Found 1399 clinical trials
VitaFlow II Transcatheter Aortic Valve System Pre-market Trial

This is a pre-market clinical investigation aiming to evaluate the safety and effectiveness of Microport CardioFlow VitaFlow II Transcatheter Aortic Valve System for the treatment of severe aortic stenosis.

transcatheter aortic valve implantation
aortic valve replacement
aortic stenosis
stenosis
  • 0 views
  • 19 Feb, 2024
  • 4 locations
Durvalumab(MEDI4736) After chemoRadioTherapy(DART) for NSCLC-a Translational and Biomarker Study

The main aim is to identify and describe biomarkers in different sample types related to chemoradiation followed by durvalumab treatment for stage III PD-L1 negative and positive non-small cell lung cancer (NSCLC) patients' eligible for curatively intended chemoradiation. The hypothesis is that clinical differences in course of disease reflect underlying …

chemoradiotherapy
neutrophil count
liver metastasis
serum bilirubin
medi4736
  • 0 views
  • 19 Feb, 2024
  • 2 locations
Cisplatin+Pembrolizumab+RT in Vulvar Cancer

This research is being done to see how well the combination of a standard of care drug, investigational drug, and radiation therapy work against unresectable vulvar squamous cell carcinoma. This research study involves the following: Cisplatin (standard of care drug) Pembrolizumab (investigational drug) Radiation Therapy (standard of care intervention)

liver metastasis
ffpe
measurable disease
liver metastases
metastasis
  • 0 views
  • 19 Feb, 2024
  • 1 location
A Study to Assess Pulsed Inhaled Nitric Oxide vs Placebo in Subjects With Mild or Moderate COVID-19

A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of pulsed inhaled iNO compared to placebo in subjects with COVID-19.

oxygen supplementation
covid-19
SARS
chest x-ray
ct scan
  • 0 views
  • 19 Feb, 2024
  • 14 locations
THE ALIGN-AR PIVOTAL TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study

To collect information about treatment for symptomatic severe Aortic Regurgitation (AR), which affects the aortic valve in the heart. Aortic regurgitation is a condition where aortic valve in the heart does not close tightly and allows some blood to leak back into the heart chamber. Symptoms of aortic regurgitation may …

aortic valve replacement
fatigue
shortness of breath
regurgitation
  • 0 views
  • 19 Feb, 2024
  • 10 locations
18F-PSMA-1007 PET Imaging to Detect Primary Prostate Cancer

To study the added value of 18F-PSMA-1007 PET to mpMRI in the detection of local prostate cancer lesions.

positron emission tomography
multiparametric magnetic resonance imaging
digital rectal examination
pet/ct scan
  • 0 views
  • 19 Feb, 2024
  • 1 location
Sympathoinhibition as a Preferred Second Line Treatment of Obesity Related Hypertension

This study is designed to investigate whether sympathoinhibition with moxonidine could provide added metabolic benefit compared to the second line therapy in the current guidelines.

amlodipine
amlodipine 5 mg
ace inhibitor
body mass index
hypertension
  • 0 views
  • 19 Feb, 2024
  • 1 location
COVID19-Convalescent Plasma for Treating Patients With Active Symptomatic COVID 19 Infection (FALP-COVID)

COVID-19 infection has spread worldwide causing several deaths in few months Convalescent Plasma from COVID 19 donors has shown huge activity in small series from Chinese patients and currently many centers from USA and the European Union are assessing its use looking to avoid mortality and prolonged hospitalizations COVID-19-related

diabetes
neutrophil count
dyspnea
fraction of inspired oxygen (fio2)
lung disease
  • 0 views
  • 19 Feb, 2024
  • 1 location
TPM Regimen (Thalidomide Prednisone and Methotrexate) in LGLL

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disease, with LGL infiltration in peripheral blood and bone marrow, hepatosplenomegaly, and cytopenia. Both T-LGLL and CLPD-NK are indolent disease and share similar biology and clinical course, and treated under the same strategy. So the investigators put them together as LGLL. The …

cytopenia
clpd-nk
lymphoid leukemia
hepatosplenomegaly
lymphoproliferative disorder
  • 0 views
  • 19 Feb, 2024
  • 9 locations
Instrumental Activities of Daily Living Approach in Home Environment for Patients With Stroke

The purpose of this study was to conduct a randomized clinical trial. Implement instrumental daily activities of daily living (A-IADL) in home rehabilitation. To explore the effect of A-IADL on stroke patients' movement, cognition, social participation, daily life function and quality of life.

  • 0 views
  • 19 Feb, 2024
  • 1 location