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Found 197 clinical trials
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with concurrent chemoradiation therapy followed by either pembrolizumab with olaparib placebo (Arm 1) or with olaparib (Arm 2) compared to concurrent chemoradiation therapy followed by durvalumab (Arm 3) in participants with unresectable, locally advanced …

chemoradiotherapy
pulmonary function test
pemetrexed
carboplatin
metastasis
  • 0 views
  • 19 Feb, 2024
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2

This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas.

nf2 gene
investigational therapy
conventional mri
meningiomatosis
meningioma
  • 0 views
  • 19 Feb, 2024
Effectiveness of Kinesiotaping and Manipulation Therapies in Drooling Management Among Children With Oral Dysphagia

Children suffering from neurological problems may have a common problem of drooling and dysphagia.There is high prevelance of neurological disorders in developing countries including Pakistan.Parents of children with disability are highly stressed and burdenised while taking care of their children.there is a need to overcome the drooling and dysphagia problems …

  • 0 views
  • 19 Feb, 2024
A Study Evaluating The Safety And Pharmacokinetics Of Escalating Doses Of RO7297089 In Patients With Relapsed Or Refractory Multiple Myeloma

This is a first-in-human Phase I, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, and pharmacokinetics of RO7297089 and make a preliminary assessment of anti-tumor activity in patients with R/R MM for whom no established therapy for MM is appropriate and available or who are intolerant to …

multiple myeloma
refractory multiple myeloma
measurable disease
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  • 19 Feb, 2024
Ibrutinib + Venetoclax in Untreated WM

This research study involves an experimental drug combination of targeted therapies. The names of the study drugs involved in this study are: Venetoclax ibrutinib

cancer
bone marrow biopsy
platelet transfusion
serum pregnancy test
plasmapheresis
  • 0 views
  • 19 Feb, 2024
Hyperpolarized Imaging for New Treatments

The introduction of triple combination CFTR modulator therapy for patients with Cystic Fibrosis (CF) with at least one copy of the deltaF508 mutation is expected to provide major health benefits, but will also require novel outcome measures that can detect CF lung disease at an early stage, capture the efficacy …

fibrosis
sweat chloride test
pulmonary function test
multiple breath washout
pilocarpine
  • 0 views
  • 19 Feb, 2024
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease

Impaired verbal communication is a cardinal symptom of Alzheimer Disease (AD) and the source of enormous distress and disability. Effective therapies for this deficit are lacking. In light of the emerging literature demonstrating that Transcranial Magnetic Stimulation (TMS) improves general cognition in subjects with Alzheimer Disease (AD), the investigators propose …

alzheimer's disease
mini-mental state examination
cognitive impairment
deficit
  • 0 views
  • 19 Feb, 2024
Erector Spinae Plane Block After Lumbar Spinal Stenosis Surgery

Management of this postoperative pain is thus important. Different pain management therapies exist. The erector spinae plane (ESP) block was described in 2016. It involves the injection of local anesthetics into the interfascial plane, deep to erector spinae muscle, allowing the blockade of the dorsal and ventral rami of the …

spinal stenosis
blockade
stenosis
lumbar spinal stenosis
analgesia
  • 0 views
  • 19 Feb, 2024
COhort for Bardet-Bield Syndrome and Alstr m Syndrome for Translational Research Monocentric Interventional Study

There are to date no specific treatments available and limited information on the natural history of the diseases. the investigators aim to establish a French cohort for these diseases to improve patient care and assess the effect of actual therapies on quality of life. The purpose of this study is …

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  • 19 Feb, 2024
The Acute Effects of Pragmatic Manual Therapy on the Range of Motion of Shoulder Joint

Manual intervention should therefore address these issues in conjunction with the other therapies. Novel interventions has been designed pilot tested for each of these factors to produce healing environment. The purpose of this study is to evaluate the effects of each individual factor and combination of all on the range …

redness
shoulder pain
range of motion
steroid injection
therapies
  • 0 views
  • 19 Feb, 2024