Found 99 clinical trials
Study to Evaluate Patients With Cerebrotendinous Xanthomatosis
The study is made up of two cohorts: a randomized double-blind crossover (placebo withdrawal with rescue) study among patients 16 years of age (adult cohort) and an open-label dose titration study among pediatric patients 1 month and <16 years of age (pediatric cohort)
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- 19 Feb, 2024
Oxytocin Treatment in Neonates and Infants With Prader-Willi Syndrome
Prospective, randomized, placebo-controlled, double-blind part of the phase III trial to assess the safety and efficacy of 4 weeks oxytocin (OT) administration on oral and social skills in neonates/infants with Prader-Willi Syndrome (PWS) aged less than 3 months at inclusion.
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- 19 Feb, 2024
Prone Positioning for Patients on General Medical Wards With COVID19
COVID-PRONE is a multicenter, pragmatic, single-blind, 2-arm, parallel, randomized controlled trial seeking to compare the pre-emptive prone positioning (i.e. encouraging patients to adopt a prone position before they require mechanical ventilation) to the control arm of standard care alone.
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- 19 Feb, 2024
Initial Attack on Latent Metastasis Using TAS-102 for ct DNA Identified Colorectal Cancer Patients After Curative Resection
This trial is a randomized, double-blind, multinational Phase III study to evaluate the efficacy and safety of preemptive treatment with FTD/TPI compared with administration of placebo as follow-up, which is the standard of care, in patients who underwent curative resection of colorectal cancer and then tested positive for ctDNA.
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- 19 Feb, 2024
KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated Nonsquamous NSCLC
This is a Phase 2, randomized, multicenter, double-blind study of the glutaminase inhibitor telaglenastat with standard-of-care pembrolizumab and chemotherapy versus placebo with standard-of-care pembrolizumab and chemotherapy for first line treatment of metastatic disease in patients with KEAP1/NRF2-mutated, stage IV, nonsquamous, non-small cell lung cancer (NSCLC).
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- 19 Feb, 2024
Mobile App as a Guide to Exercises for Patients With Chronic Stroke
Objectives: To analyze adherence to physical rehabilitation by mobile App and to evaluate the effectiveness of lumbopelvic stability exercises performed at home with the App. Material and methods: Randomized controlled single blind pilot study (n = 30). Participants with Stroke (<6 months) will be randomized between two groups (App for …
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- 19 Feb, 2024
Does Insulin Sensitivity Impact the Potential of Metformin to Slow Aging
The investigators will use a dual-site, 12- week drug intervention trial performed in a double-blind, placebo-controlled manner on 148 subjects recruited from two separate sites (Oklahoma Medical Research Foundation (OMRF) and University of Illinois Urbana-Champaign (UIUC)).
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- 19 Feb, 2024
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
Background The retina is a thin layer of tissue at the back of the eye. Retinal disease usually reduces a person s mobility because it affects how he or she moves through familiar and unfamiliar environments. Researchers want to see if a virtual reality (VR) tool can provide an easier …
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- 19 Feb, 2024
Sympathoinhibition as a Preferred Second Line Treatment of Obesity Related Hypertension
This study is designed to investigate whether sympathoinhibition with moxonidine could provide added metabolic benefit compared to the second line therapy in the current guidelines.
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- 19 Feb, 2024
GLS-1200Topical Nasal Spray to Prevent SARS-CoV-2 Infection (COVID-19) in Health Care Personnel
This clinical trial will evaluate the safety, tolerability and effectiveness of topical GLS-1200 nasal spray to reduce the incidence of confirmed, symptomatic SARS-CoV-2 infection.
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- 19 Feb, 2024