Found 1061 clinical trials
Real-life Pan-HER-blockade With Neratinib
So far, there is no data available on treatment of patients with early-stage hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2)-overexpressed/amplified breast cancer, who completed adjuvant trastuzumab-based therapy less than one year ago, in the clinical routine setting. ELEANOR - designed as a prospective, longitudinal, non-interventional study …
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- 19 Feb, 2024
- 2 locations
Trauma Specific Frailty Index
In a prospective study the primary site demonstrated the presence of frailty syndrome as a better predictor of in-hospital complications and adverse discharge disposition among geriatric trauma patients than age (10,11).
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- 19 Feb, 2024
- 1 location
DWIBS-MRI: An Adjunct to the Traditional Diagnostic Breast Imaging Evaluation
Primary Objectives To determine if MRI DWIBS can accurately identify suspicious lesions previously categorized on mammography and sonography as potentially malignant. We will also validate whether DWIBS-MRI ADC values can be used to accurately differentiate benign from malignant lesions.
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- 19 Feb, 2024
- 1 location
Survey: COVID-19 Patients Managed in the Operating Theatre of Belgian Hospitals
Information regarding the correct implementation of guidelines is as well necessary for future guidance of health care providers.
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- 19 Feb, 2024
- 1 location
Cetuximab Therapeutic Drug Monitoring in Squamous Cell Carcinoma Head and Neck Cancer Patients: Determination of the Predictive Value Exposure Levels Through a Single Arm Multicentric Study
This pilot study aimed at evaluating the mass spec method analytical performance as part of a " real life " study, evaluating the inter-patient variability of exposure levels in head and neck cancer patients, and establishing a putative link between those exposure levels and clinical outcome.
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- 19 Feb, 2024
- 1 location
Pre-hospital Tourniquet in Extremity Injury
Study Outcome Measures Primary Outcome: Incidence of arrival in shock (SBP <90) Secondary Outcomes: Demographics, comorbidities, mechanism of injury, cause of injury, diagnosis codes, procedure codes, ISS, AIS, operative management vs. non-operative management, radiologic findings, pathologic findings, tourniquet effectiveness (as determined both subjectively by trauma surgeon and objectively by presence …
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- 19 Feb, 2024
- 1 location
PanOptix and Angle Kappa
The main complaint of patients who received a presbyopia correcting lens (regardless of the design) are visual disturbances such as glare, halos (rings around lights), starbursts (rays around light sources), mainly at night. The degree of limitation or how bothered patients are varies from patient to patient.
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- 19 Feb, 2024
- 1 location
Predicting the Need for Intubation in Hospitalised COVID-19 Patients (PRED ICU COVID19)
However, the limited number of resuscitation beds and ventilators requires strict use of these scarce resources. As a significant proportion about 5% to 10%, of patients initially admitted to hospital with COVID-19 will require ventilation, it is essential to anticipate their need for resuscitation to improve the rare resource of …
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- 19 Feb, 2024
- 2 locations
A Blind Self Controlled Multicenter Clinical Trial on the Effectiveness and Safety of Noninvasive Flow Reserve Score Analysis Software for Coronary Angiography
This is a blind evaluation, self-control, multicenter clinical trial. 340 patients who need selective operation to evaluate the function of coronary artery were selected and measured with ctffr and FFR. The data of the experimental group was defined as: FFR value at the distal end of stenosis was obtained by …
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- 19 Feb, 2024
- 1 location
A Study of the Effectiveness of Venetoclax Tablets in Adult Acute Myeloid Leukemia Participants Ineligible for Standard Induction Therapy in Russian Federation
Venetoclax is a drug approved to treat Acute Myeloid Leukemia. All study participants will receive Venetoclax as prescribed by their study doctor in accordance with approved local label. Adult participants with a diagnosis of AML who are ineligible for standard induction therapy will be enrolled.
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- 19 Feb, 2024
- 3 locations