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Found 201 clinical trials
Systematic Evaluation of Ablation Techniques for Non-Paroxysmal Atrial Fibrillation.

The purpose of this study is to evaluate the safety and effectiveness of empirical posterior wall isolation (PWI), left atrial appendage electrical isolation (LAAEI) and coronary sinus isolation (CSI) when compared to pulmonary vein isolation (PVI) alone:

<ul>
  • PVI alone,
  • PVI + PWI,
  • PVI + PWI + LAAEI,
  • PVI …

    pulmonary vein isolation
    paroxysmal atrial fibrillation
    fibrillation
    chest pain
    ablation techniques
    • 0 views
    • 19 Feb, 2024
    Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B With or Without Inhibitory Antibodies to Factor VIII or IX

    Primary Objective:

    To characterize the long-term safety and tolerability of fitusiran

    Secondary Objectives:

    <ul>
  • To characterize the long-term efficacy of fitusiran as assessed by the frequency of:
  • Bleeding episodes
  • Spontaneous bleeding episodes
  • Target joint bleeding episodes
  • To characterize the effects of fitusiran on health-related quality of life (HRQOL) …

    hemophilia
    fitusiran
    haemophilia a
    antihemophilic factor
    hemarthrosis
    • 0 views
    • 19 Feb, 2024
    • 41 locations
    SAR408701 Versus Docetaxel in Previously Treated Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small Cell Lung Cancer Patients

  • The primary objective is to determine whether SAR408701 improves the overall survival (OS) when compared with docetaxel in participants with metastatic non-squamous NSCLC expressing CEACAM5 2+ in intensity in at least 50% of the tumor cell population and previously treated with standard-of-care platinum-based chemotherapy and an immune checkpoint inhibitor.
  • ul>

    squamous nsclc (non-small cell lung cancer)
    cancer
    non-squamous non-small cell lung cancer
    immune checkpoint inhibitor
    pulmonary metastasis
    • 0 views
    • 19 Feb, 2024
    • 169 locations
    Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants  

    Primary Objective:

    <ul>
  • To assess the safety profile of each SP0202 formulation and Prevnar 13 in toddlers and infants (after each and any injection).

    • 0 views
    • 19 Feb, 2024
    • 31 locations
    Study on a High-Dose Quadrivalent Influenza Vaccine Compared With Standard-Dose Quadrivalent Influenza Vaccine in Children 6 Months Through 35 Months of Age

  • To compare hemagglutination inhibition (HAI) immune response of QIV-HD to QIV-SD in participants 6 months through 35 months of age
  • To describe the HAI, seroneutralization (SN), and anti-neuraminidase (NA) immune response
  • To describe the immune response to revaccination in Season 3 (Northern Hemisphere)
  • To describe the safety profile of each …

    hemagglutination inhibition
    influenza
    quadrivalent inactivated influenza vaccine
    vaccination
    flu symptoms
    • 0 views
    • 19 Feb, 2024
    • 9 locations
    Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe

  • To describe the safety profile of MenACYW conjugate vaccine and a licensed meningococcal vaccine.
  • ul>

    immunization schedule
    febrile illness
    meningococcal conjugate
    disorders, congenital
    pertussis
    • 0 views
    • 19 Feb, 2024
    • 29 locations
    Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe

  • To describe the safety profile of MenACYW conjugate vaccine and a licensed meningococcal vaccine.
  • ul>

    immunization schedule
    febrile illness
    meningococcal conjugate
    disorders, congenital
    pertussis
    • 0 views
    • 19 Feb, 2024
    • 29 locations
    Asian Diabetes Outcomes Prevention Trial

    The aim of this study is to identify patients with DM at high risk of CVD using elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125pg/mL), and (2) intensify therapy using renin-angiotensin system (RAS) antagonists, beta-blockers and sodium glucose co-transporter-2 inhibitors (SGLT2i) for primary prevention of cardiovascular events in this high-risk …

    myocardial infarction
    coronary artery stenosis
    heart failure
    coronary revascularization
    angiotensin
    • 0 views
    • 19 Feb, 2024
    Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease

    Comparison of Angiography-derived Fractional FLow Reserve And IntraVascular Ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with CoRonary Artery Disease

    angiography
    stenosis
    heart disease
    arterial disease
    intravascular ultrasound
    • 2 views
    • 19 Feb, 2024
    The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty

    This study evaluates whether participating in a home-based exercise program leads to lower levels of complication rates and patient-reported disability after surgery. Half of the participants will be randomized into the exercise group, while the other half will be randomized into the control group.

    • 0 views
    • 19 Feb, 2024