Found 1256 clinical trials
The Effect of a Low FODMAP Diet in Irritable Bowel Syndrome Patients
Tertiary care IBS patients will be recruited for a prospective low FODMAP intervention study, hereby focusing on the reintroduction phase of the diet, where patients are blindly challenged with different FODMAP groups administered as powder, to be added to the strict FODMAP exclusion phase. During the screening phase of two …
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- 19 Feb, 2024
- 1 location
The Effect of Regional Anesthesia Techniques on Brain Tissue Oxygenation in Thoracic Surgery
This application can disrupt tissue oxygenation due to both Operation position and single lung ventilation. Thoracic epidural analgesia, which is applied as the gold standard of Thoracic Surgery, is applied prior to the operation and is provided to assist in postoperative analgesia.
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- 19 Feb, 2024
- 1 location
Safety and Early Signs of Efficacy of IL12-L19L19.
The primary objective of the study is to evaluate the safety of IL12-L19L19 and to establish MTD, as recommended dose (RD). The secondary objectives of the study are to assess early signs of efficacy, the determination of pharmacokinetic (PK) properties and the immunogenicity of IL12-L19L19.
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- 19 Feb, 2024
- 4 locations
Helping Families Pilot of a Family Resilience Program for Families Experiencing Homelessness and Parental Substance Use
For the families assigned to the treatment as usual group, they will continue to receive case management services from their residential facilities. Families in both groups will be asked to fill out 3 surveys (one at the beginning of the program, one at the end of the program, and at …
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- 19 Feb, 2024
- 1 location
The Young Heart Study
The purpose of our project is to better understand the characteristics of the young patients with coronary artery disease presenting for cardiac catheterization at our institution and to put forth a program to optimize their risk factors with a focus on gender differences. We will assess traditional and non-traditional risk …
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- 19 Feb, 2024
- 1 location
Acalabrutinib Lenalidomide and Rituximab for the Treatment of CD20 Positive Stage III-IV Grade 1-3a Follicular Lymphoma
Acalabrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as lenalidomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them …
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- 19 Feb, 2024
- 1 location
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease
In light of the emerging literature demonstrating that Transcranial Magnetic Stimulation (TMS) improves general cognition in subjects with Alzheimer Disease (AD), the investigators propose to study the effectiveness of TMS as a therapy for impaired verbal communication. The hypothesis to be tested is that TMS combined with Constraint Induced Language …
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- 19 Feb, 2024
- 1 location
Lenvatinib and Pembrolizumab Before Surgery for the Treatment of Locally Advanced Non-Metastatic Kidney Cancer
Lenvatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
- 8 views
- 19 Feb, 2024
- 1 location
Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)
The primary hypothesis is that pembrolizumab + lenvatinib is superior to SOC chemotherapy with respect to ORR per modified Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by blinded independent central review.
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- 19 Feb, 2024
- 3 locations
Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma
The innovation of this study is the combination of immune checkpoint inhibitor, Camrelizumab, and targeted drug against VEGFR, Apatinib, as an inductive therapy to treat the patients with locally advanced OSCC, followed with radical surgery and post-operative radiotherapy/chemoradiotherapy, the major pathologic response and safety will be evaluated as the primary …
- 0 views
- 19 Feb, 2024
- 1 location