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Found 67 clinical trials
Molecular & Cellular Characterisation of Oral Lichen Planus

The principal research objective is to provide enhanced understanding of the cellular and molecular events important in the pathogenesis of Oral Lichen Planus to enable improved diagnosis and development of novel treatments for patients.

lichen planus
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  • 19 Feb, 2024
Non-invasive Evaluation Program for TIPS and Follow Up Network 2 (NEPTUN2)

Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.

portosystemic shunt
hypertension
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  • 19 Feb, 2024
Neurodegenerative Diseases Registry

With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian syndromes (PS), small vessel disease (SVD) and motor neuron disease (MND). In spite of the progress of knowing the pathogenesis …

frontotemporal dementia
supranuclear palsy
lewy body dementia
brain pathology
parkinsonism
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  • 19 Feb, 2024
Improving Colonoscopy Quality for Colorectal Cancer Screening in the National VA Healthcare System

High quality screening colonoscopy is critical for colorectal cancer (CRC) prevention in Veterans. There is significant variability in colonoscopy quality in VA that is directly linked to differences in CRC incidence and death. The investigators developed the VA Endoscopy Quality Improvement Program (VA-EQuIP) that the National GI program office will …

endoscopy
screening colonoscopy
adenoma
screening for colorectal cancer
colorectal cancer screening
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  • 19 Feb, 2024
Marker Driven Selection of Patients for Prostate Biopsy and Management

The purpose of this research study is to determine if the interpretation of multiparametric MRI (mpMRI) with an algorithm called habitat risk score (HRS) in combination with a panel of blood biomarkers is more effective at detecting prostate cancer than standard of care interpretation of mpMRI with the Prostate Imaging …

digital rectal examination
tumor markers
digital rectal exam
biopsy of prostate
prostate specific antigen
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  • 19 Feb, 2024
RadioPathomics Artificial Intelligence Model to Predict nCRT Response in Locally Advanced Rectal Cancer

By the system, whether the participants achieve the pathologic complete response (pCR) will be identified based on the radiopathomics features extracted from the pre-nCRT Magnetic Resonance Imaging (MRI) and biopsy images. The predictive power to discriminate the pCR individuals from non-pCR patients, will be validated in this multicenter, prospective clinical …

adjuvant therapy
cancer
rectal cancer
chemoradiotherapy
fluorouracil
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  • 19 Feb, 2024
Prospective Trial for the Evaluation of Radiogenomics in Advanced Rectal Cancer

In patients with advanced rectal cancer, molecular subtypes will be identified by preoperative biopsy, CT, MRI / PET radiomics analysis, clinical features, and clinical features will be confirmed and compared. Also, we want to confirm the relationship between these factors and the treatment response after chemoradiotherapy before surgery.

chemoradiotherapy
cancer
rectal cancer
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  • 19 Feb, 2024
B3 for NMD: Bench to Bedside and Back

Sample and data collection at the Neuromuscular Center, The Ottawa Hospital may include blood, DNA, saliva, cerebrospinal fluid, urine and stool samples, skin or muscle biopsy, and routine diagnostic imaging studies such as electrodiagnostic studies, ultrasound, and magnetic resonance imaging.

muscle biopsy
myopathy
amyotrophic lateral sclerosis
motor neuron disease
neuromuscular diseases
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  • 19 Feb, 2024
The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Endometrial and Cervical Cancer. A Multicenter Study.

The role of small-volume lymph node disease (ITC and micro metastases) among patients with endometrial or cervical cancer submitted to sentinel node (SLN) procedure is not clearly defined. This study was designed to create a dataset of patients with lymph nodal disease. Data on type and volume of lymph nodal …

cancer
sentinel node
pathologic examination
stage cervical cancer
metastasis
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  • 19 Feb, 2024
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

At visits, participants will undergo some or all of the following: Medical history Physical exam Tests of muscle strength and volume and physical function Blood tests Pregnancy test (for some females) Skin biopsy of forearm Magnetic resonance imaging (MRI) Dual x-ray absorptiometry (DEXA). Some tests are optional.

  • 0 views
  • 19 Feb, 2024