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Found 707 clinical trials
SAR408701 Versus Docetaxel in Previously Treated Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small Cell Lung Cancer Patients

  • The primary objective is to determine whether SAR408701 improves the overall survival (OS) when compared with docetaxel in participants with metastatic non-squamous NSCLC expressing CEACAM5 2+ in intensity in at least 50% of the tumor cell population and previously treated with standard-of-care platinum-based chemotherapy and an immune checkpoint inhibitor.
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    platinum-based chemotherapy
    immune checkpoint inhibitor
    small cell lung cancer
    docetaxel
    measurable disease
    • 0 views
    • 19 Feb, 2024
    • 169 locations
    Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants  

    Primary Objective:

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  • To assess the safety profile of each SP0202 formulation and Prevnar 13 in toddlers and infants (after each and any injection).

    • 0 views
    • 19 Feb, 2024
    • 32 locations
    Study on a High-Dose Quadrivalent Influenza Vaccine Compared With Standard-Dose Quadrivalent Influenza Vaccine in Children 6 Months Through 35 Months of Age

  • To compare hemagglutination inhibition (HAI) immune response of QIV-HD to QIV-SD in participants 6 months through 35 months of age
  • To describe the HAI, seroneutralization (SN), and anti-neuraminidase (NA) immune response
  • To describe the immune response to revaccination in Season 3 (Northern Hemisphere)
  • To describe the safety profile of each …

    quadrivalent inactivated influenza vaccine
    vaccination
    influenza
    flu symptoms
    hemagglutination inhibition
    • 0 views
    • 19 Feb, 2024
    • 10 locations
    Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe

  • To describe the safety profile of MenACYW conjugate vaccine and a licensed meningococcal vaccine.
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    chronic disease
    antibiotics
    acute illness
    pertussis
    whooping cough
    • 0 views
    • 19 Feb, 2024
    • 29 locations
    Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe

  • To describe the safety profile of MenACYW conjugate vaccine and a licensed meningococcal vaccine.
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    chronic disease
    antibiotics
    acute illness
    pertussis
    whooping cough
    • 0 views
    • 19 Feb, 2024
    • 29 locations
    Asian Diabetes Outcomes Prevention Trial

    The aim of this study is to identify patients with DM at high risk of CVD using elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125pg/mL), and (2) intensify therapy using renin-angiotensin system (RAS) antagonists, beta-blockers and sodium glucose co-transporter-2 inhibitors (SGLT2i) for primary prevention of cardiovascular events in this high-risk …

    beta blocker
    type 2 diabetes mellitus
    primary prevention
    nesiritide
    angiotensin
    • 0 views
    • 19 Feb, 2024
    • 1 location
    Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease

    Comparison of Angiography-derived Fractional FLow Reserve And IntraVascular Ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with CoRonary Artery Disease

    intravascular ultrasound
    stenosis
    angiography
    arterial disease
    heart disease
    • 2 views
    • 19 Feb, 2024
    • 15 locations
    The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty

    This study evaluates whether participating in a home-based exercise program leads to lower levels of complication rates and patient-reported disability after surgery. Half of the participants will be randomized into the exercise group, while the other half will be randomized into the control group.

    • 0 views
    • 19 Feb, 2024
    • 1 location
    First-in-human Single Agent Study of SAR442085 in Relapsed or Refractory Multiple Myeloma

    Primary Objectives:

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  • Dose Escalation Part A: To determine the maximum tolerated dose (MTD) of SAR442085 administered as a single agent in patients with relapsed or refractory multiple myeloma (RRMM), and determine the recommended Phase 2 dose (RP2D) for the subsequent Expansion Part B
  • Dose Expansion Part B: To assess …

    monoclonal antibodies
    ixazomib
    thalidomide
    autologous hematopoietic stem cell transplant
    measurable disease
    • 0 views
    • 24 Nov, 2025
    • 8 locations
    Effects of a Multimodal Exercise Program on Physical Performance and Muscle Function in Middle-aged Patients With T2DM  

    The findings are expected to support early intervention strategies for healthy aging and serve as a valuable reference for clinical practice and the development of public health policies.ul>ul>

    • 0 views
    • 02 Dec, 2025
    • 3 locations