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Found 707 clinical trials
Fitusiran Prophylaxis in Male Pediatric Subjects Aged 1 to Less Than 12 Years With Hemophilia A or B

Primary Objective:

<ul>
  • To confirm appropriate dose levels of fitusiran when administered to male pediatric participants (ages 1 to <12 years of age) with severe hemophilia A or B
  • ul>

    Secondary Objective:

    <ul>
  • To characterize the safety and tolerability
  • To characterize the pharmacokinetics (PK)
  • ul>

    haemophilia a
    factor ix
    hemophilia
    antihemophilic factor
    fitusiran
    • 0 views
    • 19 Feb, 2024
    • 11 locations
    Study of SAR339375 in Patients With Alport Syndrome

    Primary Objectives:

    <ul>
  • To assess the efficacy of SAR339375 in reducing the decline in renal function
  • To assess the safety and tolerability of SAR339375
  • ul>

    Secondary Objectives:

    <ul>
  • To assess plasma pharmacokinetic (PK) parameters of the parent compound and its metabolites
  • To assess the immunogenicity of the SAR339375
  • ul>

    • 0 views
    • 19 Feb, 2024
    • 13 locations
    Multi-center Open-label Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM)

    Primary Objectives:

    <ul>
  • To evaluate the safety and tolerability of isatuximab administered subcutaneously (SC) versus intravenously (IV)
  • To evaluate the pharmacokinetics (PK) of SC and IV isatuximab
  • ul>

    Secondary Objectives:

    <ul>
  • To estimate absolute bioavailability of SC and IV isatuximab
  • To measure receptor occupancy (RO) after isatuximab SC versus IV …

    antibiotics
    arginine
    measurable disease
    parenteral administration
    antibiotic
    • 0 views
    • 24 Nov, 2025
    • 14 locations
    • 0 views
    • 19 Feb, 2024
    • 23 locations
    • 0 views
    • 01 Dec, 2025
    • 20 locations
    • 0 views
    • 19 Feb, 2024
    • 7 locations
    Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

    Primary Objectives:

    <ul>
  • Safety run-in: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM)
  • Randomized Phase 3: To demonstrate the clinical benefit of isatuximab in combination with lenalidomide and dexamethasone in the prolongation of progression-free survival when compared …

    smoldering myeloma
    multiple myeloma
    residual tumor
    minimal residual disease
    lenalidomide
    • 0 views
    • 24 Nov, 2025
    • 16 locations
    Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

    Primary Objectives:

    <ul>
  • Safety run-in: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM)
  • Randomized Phase 3: To demonstrate the clinical benefit of isatuximab in combination with lenalidomide and dexamethasone in the prolongation of progression-free survival when …

    smoldering myeloma
    multiple myeloma
    residual tumor
    minimal residual disease
    lenalidomide
    • 0 views
    • 24 Nov, 2025
    • 16 locations
    Systematic Evaluation of Ablation Techniques for Non-Paroxysmal Atrial Fibrillation.

    The purpose of this study is to evaluate the safety and effectiveness of empirical posterior wall isolation (PWI), left atrial appendage electrical isolation (LAAEI) and coronary sinus isolation (CSI) when compared to pulmonary vein isolation (PVI) alone:

    <ul>
  • PVI alone,
  • PVI + PWI,
  • PVI + PWI + LAAEI,
  • PVI …

    fibrillation
    catheter ablation
    atrial fibrillation
    pulmonary vein isolation
    ablation techniques
    • 0 views
    • 19 Feb, 2024
    • 4 locations
    Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B With or Without Inhibitory Antibodies to Factor VIII or IX

    Primary Objective:

    To characterize the long-term safety and tolerability of fitusiran

    Secondary Objectives:

    <ul>
  • To characterize the long-term efficacy of fitusiran as assessed by the frequency of:
  • Bleeding episodes
  • Spontaneous bleeding episodes
  • Target joint bleeding episodes
  • To characterize the effects of fitusiran on health-related quality of life (HRQOL) …

    haemophilia a
    hemophilia
    hemarthrosis
    antihemophilic factor
    fitusiran
    • 0 views
    • 19 Feb, 2024
    • 44 locations