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Found 349 clinical trials
Efficacy and Safety of Teicoplanin in CDAD

Primary Objective: Explore the efficacy of teicoplanin (100-200 mg administered orally twice a day for 7 to 14 days) in patients with Clostridium difficile infection-associated diarrhea and colitis Secondary Objective: Evaluate the safety of teicoplanin in patients with Clostridium difficile infection-associated diarrhea and colitis

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  • 19 Feb, 2024
  • 6 locations
NEUROwave - Xtracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

This mechanical injury leads to a cascade of biochemical and pathological changes, described as ''secondary injury'', which occurs minutes to weeks after the initial trauma and causes further neurological deterioration. This secondary cascade involves vascular changes, an inflammatory response, neurotoxicity, apoptosis and glial scarring, and further compromises neurological impairment after …

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  • 19 Feb, 2024
"CHOiCE"! Choose Health: Oncological Patients Cenetered Exercise

The aims of the intervention are to test the safety and the feasibility of an EX program. Secondary endpoints include the EX health-related skill and the quality of life. The program considers the preferences of EX of cancer survivors, giving the possibility to choose the EX modality (autonomous, with personal …

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  • 19 Feb, 2024
Video-assisted Anal Fistula Treatment (VAAFT) Versus Fistula-tract Laser Closure (Filac) Versus Conventional Seton in the Management of Anal Fistula

Anal fistula is a chronic inflammatory tract connecting an internal opening in the anal canal with one or more than one external openings in the perianal skin Aim of the work This prospective randomized control trial, we will compare video-assisted anal fistula treatment (Vaaft) and Fistula Laser closure (Filac) and …

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  • 19 Feb, 2024
Multicenter Perspective Study: Clinical Evaluation of the Persona MC With Preservation or Sacrifice of the PCL

Primary endpoint -Evaluation of the survival of the implant after 5 years of follow-up Secondary endpoints Evaluation of the survival of the implant at 10 years of follow up. Evaluation of clinical and radiographic outcomes in Italian patients undergoing total knee replacement with the Persona Medial Congruent implant with sacrifice …

knee pain
polyarthritis
avascular necrosis
osteoarthritis
patellectomy
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  • 19 Feb, 2024
A Study to Evaluate the Pharmacokinetics Safety and Tolerability of Mitapivat (AG-348) in Healthy Adult Participants

This is a Phase 1, randomized, single-dose, double-blinded, 4-period, crossover study to evaluate the pharmacokinetics, safety, and tolerability of mitapivat in healthy adult participants under fasted and fed (high-fat meal) conditions. Secondary objectives include evaluating the effect of mitapivat on electrocardiogram (ECG) parameters, including concentration-QT interval corrected for heart rate …

12 lead ECG
cervical cap
electrocardiogram
infertility
12 lead electrocardiogram
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  • 19 Feb, 2024
SGLT2 Inhibition in Older Obese Adults With Pre-diabetes

Their mechanism of action involves lowering of blood glucose concentration secondary to increased glucose excretion of glucose by the kidney. These drugs also improve body weight, blood pressure, and cardiac function.

oral glucose tolerance test
hemoglobin a1c
sglt2
diabetes
glycosylated hemoglobin
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  • 19 Feb, 2024
Safety Pharmacokinetics and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation

Phase 2: To evaluate the efficacy of isatuximab in desensitization of patients awaiting kidney transplantation. Secondary Objectives: Phase 2: To characterize the safety profile of isatuximab in kidney transplant candidates. To characterize the pharmacokinetic (PK) profile of isatuximab in kidney transplant candidates.

sar650984
chronic kidney disease
nephropathy
kidney transplant
diphenhydramine
  • 0 views
  • 19 Feb, 2024
  • 2 locations
A Study to Evaluate the Safety Tolerability and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate in Healthy Adult Volunteers

To determine the recommended Phase 2a dose (RP2D). Secondary objectives: To characterize pharmacokinetics (PK) of single dose AHCQ in healthy individuals.

chronic disease
pulse oximetry
nasopharyngeal swab
12 lead electrocardiogram
oral contraceptives
  • 0 views
  • 19 Feb, 2024
Descriptive and Evaluation Study of the Use of Pulmonary Ultrasound in the Initial Management of Pregnant Women in the Context of COVID-19

Objectives : Primary objective: To describe the lung ultrasound lesions in pregnant women in case of suspected or confirmed COVID-19 Secondary objectives: To compare the lung ultrasound lesions with chest Computed Tomography -scanner (CT-Scan) lesions To evaluate the performances of the lung ultrasound to diagnose COVID-19 in pregnant women To …

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  • 19 Feb, 2024