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Found 997 clinical trials
The Effect of Regional Anesthesia Techniques on Brain Tissue Oxygenation in Thoracic Surgery

This application can disrupt tissue oxygenation due to both Operation position and single lung ventilation. Thoracic epidural analgesia, which is applied as the gold standard of Thoracic Surgery, is applied prior to the operation and is provided to assist in postoperative analgesia.

oximetry
analgesia
intubation
one lung ventilation
single lung ventilation
  • 0 views
  • 19 Feb, 2024
Safety and Early Signs of Efficacy of IL12-L19L19.

The primary objective of the study is to evaluate the safety of IL12-L19L19 and to establish MTD, as recommended dose (RD). The secondary objectives of the study are to assess early signs of efficacy, the determination of pharmacokinetic (PK) properties and the immunogenicity of IL12-L19L19.

msi-h
squamous cell carcinoma
estrogen
screening procedures
b-cell lymphoma
  • 0 views
  • 19 Feb, 2024
18F-DCFPyL PET/CT Impact on Treatment Strategies for Patients With Prostate Cancer

The scan will be used to see how the disease has spread. Both the treatment strategies and probable disease outcomes as relevant to clinical endpoints will be assessed. This study is open to Veterans only.

definitive treatment
prostate cancer metastatic
external beam radiation therapy
salvage therapy
conventional imaging
  • 0 views
  • 19 Feb, 2024
Helping Families Pilot of a Family Resilience Program for Families Experiencing Homelessness and Parental Substance Use

For the families assigned to the treatment as usual group, they will continue to receive case management services from their residential facilities. Families in both groups will be asked to fill out 3 surveys (one at the beginning of the program, one at the end of the program, and at …

  • 0 views
  • 19 Feb, 2024
The Young Heart Study

The purpose of our project is to better understand the characteristics of the young patients with coronary artery disease presenting for cardiac catheterization at our institution and to put forth a program to optimize their risk factors with a focus on gender differences. We will assess traditional and non-traditional risk …

coronary disease
heart study
atherosclerosis
arterial disease
cardiovascular disease
  • 0 views
  • 19 Feb, 2024
Acalabrutinib Lenalidomide and Rituximab for the Treatment of CD20 Positive Stage III-IV Grade 1-3a Follicular Lymphoma

Acalabrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as lenalidomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them …

stage iii grade 2 follicular lymphoma
stage iii grade 3 follicular lymphoma
aptt
follicular lymphoma
tumor cells
  • 0 views
  • 19 Feb, 2024
Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)

The primary hypothesis is that pembrolizumab + lenvatinib is superior to SOC chemotherapy with respect to ORR per modified Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by blinded independent central review.

paclitaxel
squamous cell carcinoma
contraceptive use
cisplatin
monoclonal protein
  • 0 views
  • 19 Feb, 2024
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease

In light of the emerging literature demonstrating that Transcranial Magnetic Stimulation (TMS) improves general cognition in subjects with Alzheimer Disease (AD), the investigators propose to study the effectiveness of TMS as a therapy for impaired verbal communication. The hypothesis to be tested is that TMS combined with Constraint Induced Language …

deficit
cognitive impairment
alzheimer's disease
mini-mental state examination
  • 0 views
  • 19 Feb, 2024
Lenvatinib and Pembrolizumab Before Surgery for the Treatment of Locally Advanced Non-Metastatic Kidney Cancer

Lenvatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

aptt
chorionic gonadotropin
direct bilirubin
tumor cells
cancer
  • 8 views
  • 19 Feb, 2024
  • 1 location
Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma

The innovation of this study is the combination of immune checkpoint inhibitor, Camrelizumab, and targeted drug against VEGFR, Apatinib, as an inductive therapy to treat the patients with locally advanced OSCC, followed with radical surgery and post-operative radiotherapy/chemoradiotherapy, the major pathologic response and safety will be evaluated as the primary …

targeted therapy
squamous cell carcinoma
camrelizumab
white blood cell count
tumor angiogenesis
  • 0 views
  • 19 Feb, 2024