Found 35 clinical trials
Role of Nasal Dysbiosis in Parkinson Disease
Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such as microbial communities.
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- 19 Feb, 2024
- 2 locations
Sleepiness in Parkinson's Patients With Continuous Dopaminergic Delivery Device or Deep Brain Stimulation
Sleepiness is frequent in parkinsonian patients, increasing with the duration of disease. By patients with motor fluctuations, continuous dopaminergic delivery devices or deep brain stimulation are justified to improve the motor prognosis. Antiparkinsonian treatments, especially dopaminergic agonists, may worsen the sleepiness and thus affect the quality of life. We aimed …
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- 19 Feb, 2024
- 1 location
LRRK2 G2385R Leucocyte and Urine Biomarker Study
Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor (MLi-2) on these biomarkers, using immunoblotting and mass spectrometry.
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- 19 Feb, 2024
- 1 location
Speech Linguistic and Acoustic Markers in Parkinson's Disease
We aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. We will administer various speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls.
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- 19 Feb, 2024
- 1 location
Comparison of Outcomes in Asleep and Awake DBS With a Directional Electrode
To compare the clinical outcome of patients with Parkinson's disease (PD) treated with directional deep brain (dDBS) stimulation undergoing subthalamic deep brain stimulation operation (STN-DBS) under general anesthesia versus local anesthesia.
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- 19 Feb, 2024
- 1 location