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Found 67 clinical trials
Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MPP2+ Recurrent or Progressive Glioblastoma

This phase I trial studies the side effects and best dose of chimeric antigen receptor (CAR) T cells with a chlorotoxin tumor-targeting domain in treating patients with MPP2+ glioblastoma that has come back (recurrent) or that is growing, spreading, or getting worse (progressive). Vaccines made from a gene-modified virus may …

glioblastoma multiforme
malignant glioma
leukapheresis
serum pregnancy test
recurrent disease
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  • 19 Feb, 2024
Primary Organoid Models and Combined Nucleic Acids Therapeutics for Anti-HPV Treatments

Human papilloma virus (HPV) is responsible of the most common sexually transmitted infection. It can cause severe cancer lesions, of the cervix, vulva, vagina, penis and oropharynx. The International Agency for Cancer Research of World Health Organization (WHO) classified a dozen of HPV related high-risk cancer types, and recognized cervical …

pap smear
severe cancer
cone biopsy
sexually transmitted infection
human papillomavirus
  • 0 views
  • 19 Feb, 2024
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease. T2D and heart disease share many common risk factors such as aging, obesity and unhealthy lifestyle. Paradoxically however, while lowering blood LDL, commonly known as "bad cholesterol", …

fatty acids
omega-3 fatty acids
insulin sensitivity/resistance
diabetes
heart disease
  • 0 views
  • 19 Feb, 2024
Illusory Movements in Patients With Burns

Background. Large burns are the cause of extensive skeletal muscle devastation. The possibilities of rehabilitation of such patients are very limited, which contributes to the risk of metabolic failure and long-term musculoskeletal disorders. Illusory movements are a relatively new method of physiotherapy, which through functional proprioceptive stimulation enables the integration …

insulin resistance
insulin
musculoskeletal disorders
catabolic state
  • 0 views
  • 19 Feb, 2024
Verification of Predictive Biomarkers for Pancreatic Cancer Treatment Using Multicenter Liquid Biopsy

This study is for verification of predictive biomarkers for pancreatic cancer treatment using multi-center liquid biopsy.

cancer
pancreatic adenocarcinoma
adenocarcinoma
cancer treatment
pancreatic cancer
  • 0 views
  • 19 Feb, 2024
Predictive Value of a SNP Signature and Liquid Biopsy in Natural Killer T-cell Lymphoma

The purpose of this study is to determine the Predictive value of a SNP signature and liquid biopsy in patients with natural killer T-cell lymphoma.

  • 0 views
  • 19 Feb, 2024
Predictive Value of a mRNA Signature and Liquid Biopsy in Diffuse Large B Cell Lymphoma

The purpose of this study is to determine the predictive value of a mRNA signature and liquid biopsy in patients with Diffuse Large B cell lymphoma.

b-cell lymphoma
diffuse large b-cell lymphoma
lymphoma
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  • 19 Feb, 2024
AXillary Surgery After NeoAdjuvant Treatment

Different strategies (axillary lymph node dissection, sentinel node biopsy, targeted axillary dissection) are currently used in different countries. A prospective analysis comparing these techniques regarding feasibility, safety, morbidity and surgical effort is urgently needed.

fine needle aspiration
sentinel node
lymphadenectomy
axillary lymph node dissection
systemic therapy
  • 0 views
  • 19 Feb, 2024
Lyon Granulomatous Hepatitis Study

This is a retrospective study conducted from January 2008 to December 2016 proposed to all patients with granulomatous hepatitis followed in the internal medicine and / or Hepato-gastroenterology departments (Croix-Rousse Hospital, Edouard-Herriot Hospital, Lyon Sud Hospital Center). This study will cover 596 patients who had a liver biopsy showing granulomas. …

  • 0 views
  • 19 Feb, 2024
A Prospective Cohort Study of Chinese Patients With Pulmonary Nodules: Prediction of Lung Cancer Using Noninvasive Biomarkers

The broad goals of this study is to identify changes in genomic landscape during transition from stage 0 to stage 1 lung cancer. This study intends to determine whether diagnostic biomarkers measured in minimally invasive biospecimens are able to correlate molecular, clinical and imaging features to distinguish malignant from benign …

cancer
ct scan
lung cancer
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  • 19 Feb, 2024