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Found 576 clinical trials
Genetic Characteristics of Metastatic Breast Cancer Patients

  • At disease progression after 1st line treatment for MBC, blood sample (20cc) will be obtained (tissue; optional)
    • ul>

    (2) WES, RNASeq, ctDNA, Exosome

    <ul>
  • We will analyze genomic characteritics using WES, RNASeq, ctDNA, Exosome.
    • ul>

    cancer
    breast cancer
    stage iv breast cancer
    • 0 views
    • 19 Feb, 2024
    • 1 location
    Safety Pharmacokinetics and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation

    ul>

    Secondary Objectives:

    <ul>
  • Phase 2: To characterize the safety profile of isatuximab in kidney transplant candidates.

    • kidney transplant
    sar650984
    nephropathy
    isatuximab
    diphenhydramine
    • 0 views
    • 19 Feb, 2024
    • 2 locations
    MTD Safety and Efficacy of NYH817G and NYH100P in Monotherapy and Combination in Patients With Advanced Solid Tumors

    ul>

    • 0 views
    • 19 Feb, 2024
    • 1 location
    Cervical Ripening Balloons for Same-Day Cervical Prep (CRB)

  • How acceptable is cervical preparation with cervical ripening balloon for same-day outpatient D&E?
    • ul>

    Participants will:

    <ul>
  • Have cervical preparation with cervical ripening balloon (experimental group) or osmotic dilators (usual care group)
  • Complete two surveys, one about the cervical preparation and one about the D&E procedure
    • ul>

    • 0 views
    • 12 May, 2025
    • 1 location
    Dose De-escalation Study of the PI3k Alpha/Delta Inhibitor Copanlisib Given in Combination With the Immunotherapeutic Agents Nivolumab and Rituximab in Patients With Relapsed/Refractory Indolent Lymphoma

    Patients with relapsed or refractory follicular or marginal zone lymphoma who have received at least one prior line of therapy will receive

    <ul>
  • Copanlisib IV: day 1, 8, 15 every 28 days
  • Nivolumab IV: Cycle 1 days 1 and 15; then day 1 only
  • Rituximab IV: Cycle 1 days …

    symptomatic congestive heart failure
    stem cell transplant
    flow cytometry
    investigational treatment
    nivolumab
    • 0 views
    • 19 Feb, 2024
    • 1 location
    Descriptive and Evaluation Study of the Use of Pulmonary Ultrasound in the Initial Management of Pregnant Women in the Context of COVID-19

    Objectives :

    Primary objective:

    To describe the lung ultrasound lesions in pregnant women in case of suspected or confirmed COVID-19

    Secondary objectives:

    <ul>
  • To compare the lung ultrasound lesions with chest Computed Tomography -scanner (CT-Scan) lesions
  • To evaluate the performances of …

    • 0 views
    • 19 Feb, 2024
    • 1 location
    A Study to Investigate the Pharmacokinetics and Safety of Dupilumab in Participants ≥6 Months to <18 Years of Age With Prurigo Nodularis

    ul>

    The total number of planned study visits for each participant will be 6.

    • 0 views
    • 14 May, 2025
    • 6 locations
    A Multinational Randomized Double-blind Placebo-controlled Study to Assess the Efficacy Pharmacodynamics Pharmacokinetics and Safety of Venglustat in Late-onset GM2

    Primary Objectives:

    Primary population (adult participants with late-onset GM2 gangliosidosis): To assess the efficacy and pharmacodynamics (PD) of daily oral dosing of venglustat when administered over a 104-week period

    Secondary population (participants with juvenile/adolescent late-onset GM2 gangliosidosis, GM1 gangliosidosis, saposin C deficiency, sialidosis type 1 or …

    • 0 views
    • 19 Feb, 2024
    • 2 locations
    Multicenter Perspective Study: Clinical Evaluation of the Persona MC With Preservation or Sacrifice of the PCL

    Primary endpoint

    -Evaluation of the survival of the implant after 5 years of follow-up

    Secondary endpoints

    <ul>
  • Evaluation of the survival of the implant at 10 years of follow up.
  • Evaluation of clinical and radiographic outcomes in Italian patients undergoing total knee replacement …

    avascular necrosis
    polyarthritis
    osteoarthritis
    knee arthroplasty
    knee pain
    • 0 views
    • 19 Feb, 2024
    • 1 location
    PROPHET Study: ctDNA-Guided Personalized Induction Immunochemotherapy for NSCLC (PROPHET)

    Researchers will use ctDNA dynamics to guide the cycles of induction treatment to see if some patients can avoid excessive cycles of treatment.--UATul>

    • 0 views
    • 19 May, 2025