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Found 660 clinical trials
Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

The investigators are doing this study to find out whether lowering the dose of postoperative radiation therapy and targeting a smaller area of tissue for treatment is as effective as the standard dose and volume of radiation therapy to control soft tissue sarcoma after surgery. They also want to find …

soft tissue sarcoma
serum pregnancy test
sarcoma
primary tumor
sarcoma of the extremity
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  • 19 Feb, 2024
Establishment of a Prospective Clinical-biological Database

A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical data to improve knowledge about cancer and help to develope new cancer treatments. This database is specific to Sarcoma

cancer
sarcoma
  • 0 views
  • 19 Feb, 2024
A Study of SY 5609 a Selective CDK7 Inhibitor in Advanced Solid Tumors

This is a dose escalation study and will be the first to administer SY-5609 alone to humans with select advanced solid tumors and in combination with Fulvestrant to patients with HR positive, HER2-negative breast cancer.

solid tumor
her2-negative breast cancer
stage iv breast cancer
solid tumour
her2/neu-negative breast cancer
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  • 19 Feb, 2024
Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields

The participants are being treated with Tumor Treating Fields (TTFields) for malignant glioma, and this type of treatment may cause skin-related side effects. This study will test whether using clindamycin and triamcinolone topical lotions can prevent skin-related side effects of TTFields.

topical agents
tumor treating fields therapy
glioblastoma multiforme
glioma
triamcinolone topical
  • 0 views
  • 19 Feb, 2024
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

This study is an open-label, international, multi-center, Phase 2 study in adult patients with recurrent, locally-advanced or metastatic solid tumors, which harbor the NRG1 gene fusion.

solid tumor
gene fusion
indirect bilirubin
gilbert's syndrome
seribantumab
  • 0 views
  • 19 Feb, 2024
Clinical Trial to Evaluate AB011 Injection in Patients With CLDN18.2-positive Advanced Solid Tumors

This is an open, two-stage, phase I study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of AB011 injection in patients with CLDN18.2-positive advanced solid tumors.

solid neoplasm
solid tumour
treatment regimen
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  • 19 Feb, 2024
Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer

This phase I trial studies how well cemiplimab before and after surgery works in treating patients with high risk cutaneous squamous cell cancer. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow …

international normalized ratio
hair thinning
neuropathy
monoclonal antibodies
neutrophil count
  • 0 views
  • 19 Feb, 2024
A Study of BLYG8824A in Participants With Locally Advanced or Metastatic Colorectal Cancer

This study will evaluate the safety, tolerability, and pharmacokinetics of BLYG8824A and will make a preliminary assessment of the anti-tumor activity of BLYG8824A in patients with locally advanced or metastatic colorectal cancer.

antibody therapy
measurable disease
oxaliplatin
EGFR
irinotecan
  • 0 views
  • 19 Feb, 2024
A Safety and Tolerability Study of NC410 in Subjects With Advanced or Metastatic Solid Tumors

This research study is studying a new drug, NC410, as a possible treatment for advanced or metastatic solid tumors.

measurable disease
hysterectomy
solid tumour
metastasis
systemic therapy
  • 0 views
  • 19 Feb, 2024
Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MPP2+ Recurrent or Progressive Glioblastoma

Vaccines made from a gene-modified virus may help the body build an effective immune response to kill tumor cells.

tumor cells
measurable disease
glioma
glioblastoma multiforme
karnofsky performance status
  • 0 views
  • 19 Feb, 2024