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Found 73 clinical trials
4SCAR-CD44v6 T Cell Therapy Targeting Cancer

The purpose of this clinical trial is to assess the feasibility, safety and efficacy of 4SCAR-CD44v6 T-cell therapy targeting multiple cancers. The study also aims to learn more about the function of the CD44v6 CAR-T cells and their persistency in the patients.

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  • 19 Feb, 2024
Multimodality Treatment in Stage III Non-small Cell Lung Cancer (NSCLC)

Resectable, locally advanced NSCLC with involvement of mediastinal lymph nodes (N2) is associated with a high risk of (systemic) recurrence despite neo-adjuvant chemotherapy. Neo-adjuvant immunotherapy is a promising additional treatment modality aiming at increasing local control and better tackling micrometastases at the time of radical local treatment. Radiotherapy is thought …

pulmonary function test
treatment regimen
complete excision
pneumonectomy
blood transfusion
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  • 19 Feb, 2024
SAR408701 Versus Docetaxel in Previously Treated Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small Cell Lung Cancer Patients

Primary Objectives: Study is designed with two primary endpoints that will be analyzed on randomized participants at the time of the cutoff date for each given analysis (progressive free survival [PFS] and overall survival [OS]). Study success is defined either on PFS or OS The primary objective is to determine …

squamous nsclc (non-small cell lung cancer)
cancer
non-squamous non-small cell lung cancer
immune checkpoint inhibitor
pulmonary metastasis
  • 0 views
  • 19 Feb, 2024
  • 169 locations
The Value of Palliative Primary Tumor Resection in Metastatic Colon Cancer

The aim of this trial is to evaluate the value of palliative primary tumor resection in colon cancer patients with initially unresectable metastases and a positive response to induction chemotherapy which depends on gene testing. The primary endpoint is to evaluate overall survival.

cancer
mfolfox6
stage iv colon cancer
xelox
colon cancer
  • 0 views
  • 19 Feb, 2024
Role of Lymphnode Dissection in Men With Prostate Cancer Treated With Radical Prostatectomy

It allows the assessment of possible but unlikely lymph nodes metastases. In case of lymph node metastasis, depending on the number of affected lymph nodes, an adjuvant radiation with or without additional hormone therapy may be discussed in order to stop or delay further progression of the disease.

cancer
endocrine therapy
lymph node metastases
metastasis
immunological adjuvant
  • 0 views
  • 19 Feb, 2024
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus

Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.

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  • 19 Feb, 2024
Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis

The purpose of this study is to determine the efficacy of adjuvant HIPEC with Mitomycin C after colectomy in the treatment of colorectal cancer patients at high risk of peritoneal carcinomatosis.

hyperthermic intraperitoneal chemotherapy
colectomy
peritoneal carcinomatosis
colorectal cancer
systemic chemotherapy
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  • 19 Feb, 2024
bpMRI and Risk Based Shared Clinical Decision Making in Prostate Cancer Diagnosis

The shortcoming of the pre-biopsy prostate MRI approach is the recommendation to biopsy all men post-MRI even if there is no lesion seen in MRI, ie. risk of PCa is very low. Therefore, the primary objective of this trial is to compare if there is a difference between significant cancer …

digital rectal examination
cancer diagnosis
biopsy of prostate
  • 0 views
  • 19 Feb, 2024
Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases

Spine radiosurgery (SRS) utilizes advanced treatment planning with focused x-rays to deliver one to four high dose treatments to the spine to help relieve pain and/or neurologic symptoms. Spine SRS uses special equipment to position the participant and guide the focused beams toward the area to be treated and away …

external beam radiation therapy
soft tissue sarcomas
metastasis
x-rays
karnofsky performance status
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  • 19 Feb, 2024
Codman Catheter/Synchromed Pump Hepatic Artery Chemotherapy for Unresectable Colorectal Metastases/Intrahepatic Cholangiocarcinoma

This study aims to test the safety of hepatic artery infusion pump placement, a standard surgical procedure, and intraarterial chemotherapy initiation with the standard medication floxuridine (FUDR), using the Medtronic Synchromed II pump combined with the Codman arterial catheter in patients with unresectable (not removable by surgery) liver metastases from …

immunodeficiency
metastasis
metastatic adenocarcinoma
dexamethasone
hepatic arterial infusion
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  • 19 Feb, 2024