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Found 254 clinical trials
A Study to Assess the Effect of Fluvoxamine and Smoking on Pharmacokinetics ( the Movement of Drugs Within the Body) of AZD4635 in Healthy Volunteers

This study is a Phase I, open-label, non-randomized, 2-period, fixed-sequence study in healthy volunteers who are either smokers or non-smokers, performed at a single Clinical Unit.

  • 0 views
  • 19 Feb, 2024
Effect of Food on the Pharmacokinetics of ASTX660 in Healthy Volunteers

This is a Phase 1, single-dose, open-label, randomized, three-period, three-way crossover study in which healthy adult participants will receive three separate single-dose administrations of ASTX660 capsules under three different conditions.

systolic blood pressure
tubal ligation
oophorectomy
hysterectomy
body mass index
  • 0 views
  • 19 Feb, 2024
Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer

This study will compare the effects on cardiorespiratory fitness (CRF) of aerobic exercise in different amounts (number of minutes/session) over different periods of time (number of weeks). Aerobic exercise is physical activity of light-to-moderate intensity that uses the large muscle groups (muscles in your legs, buttocks, back, and chest) and …

  • 0 views
  • 19 Feb, 2024
Effects of Tolperisone on Measures of Drowsiness and Cognitive Function

A Randomized, 4-Period, Crossover Study to characterize the effects of tolperisone 200 mg and 400 mg (supratherapeutic dose) three times a day (TID) over 3 days of dosing on measures of simulated driving performance, cognitive function and drowsiness and compared to placebo and cyclobenzaprine (single-day, residual effect, multiple-day).

  • 0 views
  • 19 Feb, 2024
Trastuzumab Combined With Pyrrolidine and Chemotherapy for Locally HER2 Positive Breast Cancer

This study is a one-arm, open, phase II clinical study, and the study subjects are locally advanced and inflammatoryPatients with sexual or early HER2-positive breast cancer entered the trial period after signing informed consentTo evaluate trastuzumab combined with pyrrolitinib and chemotherapy regimen (TCbH+Py) for HER2 positive breastPathologic complete response rate …

HER2
trastuzumab
cancer chemotherapy
invasive breast cancer
pyrotinib
  • 0 views
  • 19 Feb, 2024
Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer

Half of the patients will receive tocotrienol and the other half placebo. Treatment is planned for a period of maximum six months and will be discontinued earlier in case of progression or unacceptable toxicity.

renal function
cancer metastatic
colorectal cancer
leucovorin
oophorectomy
  • 0 views
  • 19 Feb, 2024
Ultra - Brief Crisis IPT-A Based Intervention for Suicidal Children and Adolescents (IPT-A-SCI)

The current adaptation of IPT-A is comprised of five weekly sessions, followed by monthly follow-up caring email contacts to the patients and their parents, over a period of three months.

suicide
depressive symptoms
suicidal
psychotherapy
depression
  • 0 views
  • 19 Feb, 2024
Benefits of Exercise in Alzheimer's Disease

This study will involve 30 randomized patients to take part in the out-patient exercise program and 30 patients to continue with their regular activities over a 6-month period. Once that period is over, half of the 30 patients who participated in the outpatient exercise program will continue in the program …

cognitive assessment
dementia
aerobic exercise
neuropsychological test
behavioral symptoms
  • 4 views
  • 19 Feb, 2024
  • 1 location
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia

The study consists of a 6 month randomized, double blind, placebo-controlled period, followed by 1 year of treatment with crinecerfont. Duration of participation is approximately 20 months.

congenital adrenal hypoplasia
deficiency
adrenaline
  • 0 views
  • 19 Feb, 2024
Evaluation of a New Supporting Ostomy Product

It is the expectation that median wear time is slightly reduced in the period when subjects are using the supporting product with their ostomy appliance. Long-term benefits of the test product may be less skin redness, less worry of leakage and/or improvement in quality of life and social activities.

  • 0 views
  • 19 Feb, 2024