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Found 198 clinical trials
Intratumoral Tilsotolimod a TLR-9 Agonist Together With Intratumoral Ipilimumab and Intravenous Nivolumab in Patients With Advanced Cancers

The trial will be divided into two parts:

PART A:

the first part will assess the safety of two regimen and will recruit patients with all types of injectable solid malignancies

PART B:

the second part will include 3 expansion cohorts of …

irinotecan
EGFR
oxaliplatin
advanced cancer
metastatic melanoma
  • 0 views
  • 19 Feb, 2024
VARA (Virtual and Augmented Reality Applications in Rehabilitation): Motor Rehabilitation Protocol With GRAIL for Patients Affected by Hemiparesis

  • walking speed increase (but with the priority of the walking pattern)
  • increase in the resistance
  • Stregthening of the support reaction
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    weakness
    hemiparesis
    • 0 views
    • 19 Feb, 2024
    A Study to Evaluate the Safety Tolerability and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate in Healthy Adult Volunteers

  • To determine the recommended Phase 2a dose (RP2D).
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    Secondary objectives:

    To characterize pharmacokinetics (PK) of single dose AHCQ in healthy individuals.

    chronic disease
    bilateral oophorectomy
    oximetry
    nasopharyngeal swab
    chloroquine
    • 0 views
    • 19 Feb, 2024
    A Study of Subcutaneous Risankizumab Injection for Pediatric Participants With Moderate to Severe Plaque Psoriasis to Assess Change in Disease Symptoms

    Part 2: Participants aged 12 < 18 will receive;

    <ul>
  • Period A: Risankizumab or ustekinumab based on body weight followed by;
  • Period B: Risankizumab or no treatment.

    risankizumab
    pediatric
    blood tests
    inflammatory disease
    psoriasis
    • 0 views
    • 19 Feb, 2024
    Mobility Protocol Adapted for Advanced Visually Impaired Subjects

    People Retinitis Pigmentosa therefore encounter a large number of difficulties in daily life, specifically for:

    <ul>
  • Visual research
  • Visuo-motor coordination in tasks requiring fine motor control
  • Visuo-motor coordination in mobility tasks
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    This study aims to assess the difficulties in the daily life of subjects with …

    low vision
    amblyopia
    retinitis
    cognitive disorders
    visual impairment
    • 0 views
    • 19 Feb, 2024
    A Study Evaluating Safety and Therapeutic Activity of THOR-707 in Adult Subjects With Advanced or Metastatic Solid Tumors (THOR-707)  

    ul>

    • 0 views
    • 09 Aug, 2024
    • 1 location
    Avelumab and Methotrexate in in Low-risk Gestational Trophoblastic Neoplasias as First Line Treatment

  • Cytotoxicity of avelumab is mediated through antibody dependent cell cytotoxicity (ADCC) by NK cells.
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    • 0 views
    • 19 Feb, 2024
    CAD/CAM Fixed Retainers vs. Conventional Multistranded Fixed Retainers in Orthodontic Patients. Comparison of Stability Retainer Failure Rate Adverse Effects Cost-effectiveness and Patient Satisfaction. A Randomized Controlled Clinical Trial

    ul>

    • 0 views
    • 19 Feb, 2024
    Study to Evaluate the Safety Tolerability Pharmacokinetics and Efficacy of Remdesivir (GS-5734 ) in Participants From Birth to < 18 Years of Age With Coronavirus Disease 2019 (COVID-19)

    The primary objectives of this study are to evaluate the safety, tolerability, and pharmacokinetics (PK) of remdesivir (RDV) in participants with laboratory-confirmed coronavirus disease 2019 (COVID-19) aged 0 days to < 18 years.

    PCR test
    acute respiratory syndrome (sars)
    covid-19
    remdesivir
    coronavirus infection
    • 0 views
    • 19 Feb, 2024
    Study of Safety and Efficacy of BZ019 in (R/R) Large B-cell Lymphoma

    This is an open-label, multicenter, dose-escalation phase 1 study to determine the Safety and Efficacy of BZ019 in relapsed or refractory CD19+ B-cell Lymphoma subjects.

    • 0 views
    • 19 Feb, 2024