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Found 106 clinical trials
CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer

Women with Hormone Receptor (HR)+ Human Epidermal growth factor Receptor (HER)2- metastatic breast cancer are eligible to a randomized trial. Patients receiving standard first line therapy for metastatic HR+ Breast cancer(BC) (letrozole+palbociclib) are randomly assigned to also receive Stereotactic Body Radiation Therapy(SBRT) to each metastatic lesion.

oestrogen receptor positive breast cancer
tamoxifen
HER2
anticoagulant therapy
international normalized ratio
  • 0 views
  • 19 Feb, 2024
Exercise and Tumor Blood Flow in Breast Cancer Patients

This research aims at investigating tumor blood flow response to acute exercise in human cancer patients. It is hypothesized and expected that acute exercise increases tumor blood flow, which could plausibly increase the efficacy of cancer treatment.

cancer treatment
  • 0 views
  • 19 Feb, 2024
Sentinel Lymph Node Biopsy With Hybrid Technique in Breast Cancer

Sentinel lymph node (SLN) biopsy is the gold standard method to stage axilla in breast cancer. The aim of the study is to compare the efficiency of various methods to identify SLN is breast cancer patients.

sentinel node
sentinel lymph node biopsy
excisional biopsy
  • 0 views
  • 19 Feb, 2024
Hypofractionation And Ultra-Hypofractionation In Adjuvant Radiotherapy For Breast Cancer

Prospective randomized study comparing 5 fractions in alternative days to standard 15 fractions regarding effectiveness and feasibility during adjuvant treatment in breast caner patients aged above 50 years

ct scan chest
immunomodulators
invasive breast cancer
cancer
ct scan
  • 0 views
  • 19 Feb, 2024
Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer.

Several studies are investigating the anti-tumor effect of metformin in early breast cancer. However, the enhancing effect of metformin on anti-tumor immunity has only been demonstrated in animal models. This study examines the immune effect of metformin in breast cancer patients treated with preoperative chemotherapy.

metformin
metastasis
cancer
preoperative chemotherapy
breast carcinoma
  • 0 views
  • 19 Feb, 2024
Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients

This is an open label, single arm, multicenter, phase Ib study to evaluate the safety and clinical activity of the combination of ipatasertib, trastuzumab and pertuzumab in patients with unresectable locally advanced or metastatic HER2-positive breast cancer with tumors harboring PIK3CA mutations, candidates to receive maintenance HP after first line …

breast adenocarcinoma
invasive breast cancer
cancer
her2-positive breast cancer
her2/neu-positive breast cancer
  • 0 views
  • 19 Feb, 2024
Neoadjuvant Endocrine Therapy Tolerance in Geriatric Early Stage ER+ Breast Cancer

This single arm pilot study evaluates the use of neoadjuvant endocrine therapy in women with early stage ER+ breast cancer who are 70 years or older and are scheduled to have breast conservation surgery (BCS). The purpose of this study is to see if tolerance of neoadjuvant endocrine therapy helps …

HER2
hormone therapy
aromatase inhibitor
tamoxifen
endocrine therapy
  • 0 views
  • 19 Feb, 2024
Optimizing Quality of Life in Women Living With Metastatic Breast Cancer

The purpose of this study is to develop and tailor an intervention program to improve the quality of life in women living with metastatic breast cancer. In the first phase of this study, we conducted patient focus groups to gather information about the unique challenges of living with MBC and …

stage iv breast cancer
female breast cancer
acceptance and commitment therapy
cancer
breast cancer
  • 0 views
  • 19 Feb, 2024
Trastuzumab Combined With Pyrrolidine and Chemotherapy for Locally HER2 Positive Breast Cancer

This study is a one-arm, open, phase II clinical study, and the study subjects are locally advanced and inflammatoryPatients with sexual or early HER2-positive breast cancer entered the trial period after signing informed consentTo evaluate trastuzumab combined with pyrrolitinib and chemotherapy regimen (TCbH+Py) for HER2 positive breastPathologic complete response rate …

HER2
targeted therapy
her2+ breast cancer
invasive breast cancer
cancer
  • 0 views
  • 19 Feb, 2024
Pyrotinib Trastuzumab Pertuzumab and Nab-paclitaxel as Neoadjuvant Therapy in HER2-positive Breast Cancer

This study aims to evaluate the efficacy and safety of pyrotinib in combination with trastuzumab, pertuzumab and nab-paclitaxel as neoadjuvant therapy in early stage or locally advanced HER2-positive breast cancer.

HER2
breast cancer stage
her2 positive breast carcinoma
erbb2 gene amplification
progesterone
  • 0 views
  • 19 Feb, 2024