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Found 2,831 clinical trials

D Dongying Zhang, doctor

Change of NLRP3 Inflammasome Expression Level Symptoms and Functional Status in HFpEF Patients Treated With ARNI

Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction(HFpEF). But there is no study reported the relationship between NLRP3 inflammasome and HFpEF. In this study, investigators propose a scientific hypothesis that the expression of NLRP3 inflammasome is elevated in patients with HFpEF, and the level …

100 years and younger All Phase N/A
K Kara Smith, MD

Speech Linguistic and Acoustic Markers in Parkinson's Disease

We aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. We will administer various speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. We will also explore the associations between genetic factors and speech and …

18 years and older All Phase N/A
H Hongwei Li, M.D

Effect of CI on Prognosis in the Elderly Patients With ACS

This study aims to investigate the incidence and characteristics of cognitive Impairment(CI) in the elderly patients with acute coronary syndrome (ACS), and to determine whether CI are predictive of the prognosis of major adverse cardiovascular events (MACE) and mortality.

65 years and older All Phase N/A
W Weidong Han, MD, PhD

Radiomics-based Artificial Intelligence System to Predict Neoadjuvant Treatment Response in Rectal Cancer

In this study, investigators utilize a radiomics prediction model to predict the tumor response to neoadjuvant chemoradiotherapy (nCRT) before the nCRT is administered for patients with locally advanced rectal cancer (LARC). Previously, the radiomics prediction model has been constructed based on the radiomics features extracted from pretreatment Magnetic Resonance Imaging …

18-75 years All Phase N/A
A Atef MM Darwish, MD PhD

Effects of Peri Partum Integrated Nursing Care Versus Routine Care in Placenta Previa : A Randomized Controlled Trail

At our institution, the annual number of placenta previa was 494 cases (1.7%); of whom 95 cases (19.2%) were proved to have a placenta accreta. Perioperatively, they are subjected to regular care of a tertiary university hospital. This study aims to determine the effectiveness of peri partum integrated nursing care …

20-40 years Female Phase N/A
X Xinjuan Fan, MD, PhD

RadioPathomics Artificial Intelligence Model to Predict nCRT Response in Locally Advanced Rectal Cancer

In this study, investigators utilize a radiopathomics integrated Artificial Intelligence (AI) supportive system to predict tumor response to neoadjuvant chemoradiotherapy (nCRT) before its administration for patients with locally advanced rectal cancer (LARC). By the system, whether the participants achieve the pathologic complete response (pCR) will be identified based on the …

18-75 years All Phase N/A
M Mouwang Zhou, Doctor

Quantitative Evaluation of Muscle Tone Using Elastic Ultrasound

The test subjects were selected from patients with clinical manifestations in muscle tone and healthy volunteers. Target muscles includes elbow flexor, elbow extensor, plantar flexor and ankle dorsi flexor. Thirty patients and 10 healthy subjects were given three assessment methods to measure muscle tension: modified Ashworth rating scale, elastic ultrasound …

18-80 years All Phase N/A
A Amy Miller, RPh, PharmD

TEGSEDI Pregnancy Surveillance Program

This is a worldwide safety surveillance study of pregnancy outcomes in women with hATTR-PN who may have been exposed or were not exposed to TEGSEDI prior to or during the pregnancy and of pediatric outcomes up to 1 year of age.

100 years and younger Female Phase N/A
J Jacopo Antonino Vitale, PhD

Sex & Sleep in Athletes

Achieving the correct quantity and quality of sleep is essential for the health and recovery processes of the athlete; night rest is often negatively influenced by many variables, including: high training loads, long-range trips, evening competitions, and / or high levels of anxiety and stress. High training loads can therefore …

18-40 years All Phase N/A
S Sameh M Hakim, MD

Surface Landmarks and C-length as Predictors of Depth of Right IJV Catheter Insertion: A TEE-Guided Study

The primary aim of the current study is to examine the accuracy of the C-distance or surface landmarks in determining the length of central venous catheter (CVC) that is required to place the catheter tip at the mid-superior vena cava (SCV) as confirmed by transesophageal echocardiography (TEE). A secondary aim …

18 years and older All Phase N/A

Simplify language using AI