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Found 660 clinical trials
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

An open-label, multi-center, single and cyclic ascending dose study of P-PSMA-101 autologous CAR-T cells in patients with mCRPC.

metastatic hormone refractory prostate cancer
metastatic cancer
metastatic castration-resistant prostate cancer
cancer
measurable disease
  • 0 views
  • 19 Feb, 2024
Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Intravenous immunoglobulin therapy may improve pneumonitis. It is not yet known whether giving infliximab and intravenous immunoglobulin therapy will work better in treating …

herpes
intravenous immunoglobulin
blood test
hysterectomy
infliximab
  • 0 views
  • 19 Feb, 2024
Microbiome and Rectal Cancer

The purpose of our study is to determine if an association exists between the microbiome of those with rectal adenocarcinoma who are complete pathologic responders and those who have a partial or no response to neoadjuvant therapy.

rectal cancer
neoadjuvant therapy
adenocarcinoma of rectum
chemoradiotherapy
cancer
  • 0 views
  • 19 Feb, 2024
Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers

The purpose of this study is to develop a new drug treatment to reverse tumor resistance to radioiodine in BRAF mutant tumors so that radioiodine can be given to shrink tumors. This study is also being done to find out the highest doses of copanlisib and vemurafenib that, when given …

absolute neutrophil count
thyroid carcinoma
external beam radiation therapy
braf v600e
vemurafenib
  • 0 views
  • 19 Feb, 2024
Delayed Initiation of Olaparib Maintenance Therapy in Platinum Sensitive Recurrent Ovarian Cancer

The purpose of this study is to test if delaying the start of the olaparib until there is a rise in a tumor marker called CA-125 will result in a longer time until the next or different treatment for the patient's cancer. The study will also evaluate how delaying the …

olaparib
recurrent ovarian cancer
platinum-based chemotherapy
peritoneal cancer
solid tumour
  • 0 views
  • 19 Feb, 2024
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

growth factor
immunohistochemistry
cancer therapy
chordoma
karnofsky performance status
  • 0 views
  • 19 Feb, 2024
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

i131 mibg therapy
mibg
cytokine release syndrome
solid tumour
metaiodobenzylguanidine
  • 0 views
  • 19 Feb, 2024
A Study of BPI-1178 in Patients With Advanced Solid Tumor and HR+/HER2- Breast Cancer

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics of BPI-1178 in subjects with advanced solid tumor, as well as the subjects with advanced hormone receptor-positive(HR+)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer.

her2/neu-negative breast cancer
absolute neutrophil count
epidermal growth factor
erbb2
solid tumour
  • 0 views
  • 19 Feb, 2024
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity

This study will investigate the effects of atezolizumab on select cancer types in people whose analysis of tumour DNA and RNA indicates they may be sensitive to atezolizumab. This study aims to determine if the information from the cancer genome analysis corresponds with the effects of atezolizumab on individuals and …

absolute neutrophil count
lung cancer
atezolizumab
liver metastases
metastatic cancer
  • 0 views
  • 19 Feb, 2024
Study of Tumor Infiltrating Lymphocytes Following CCRT in the Treatment of Patients With Cervical Carcinoma

A Phase II trial to study the effectiveness and security of cisplatin concurrent chemoradiotherapy plus TIL versus cisplatin concurrent chemoradiotherapy only in treating patients with FIGO stage IIIA to IVA cervical carcinoma.

adenosquamous carcinoma
squamous cell carcinoma
cervical carcinoma
cervical cancer
cisplatin
  • 0 views
  • 19 Feb, 2024