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Found 660 clinical trials
bpMRI and Risk Based Shared Clinical Decision Making in Prostate Cancer Diagnosis

Therefore, the primary objective of this trial is to compare if there is a difference between significant cancer detection rate in men undergoing prostate biopsies after MRI scan compared to men undergoing post-MRI prostate biopsies only after a shared decision-making based on prostate cancer risk estimation.

biopsy of prostate
cancer diagnosis
digital rectal examination
  • 0 views
  • 19 Feb, 2024
The Impact of Low Pressure Pneumo in RARP II

The purpose of this study is to evaluate clinical significance of low pressure pneumoperitoneum during robotically assisted radical prostatectomy (RARP).

prostatectomy
  • 0 views
  • 19 Feb, 2024
Modality of Adjuvant Radiotherapy and Chemotherapy for Stage Endometrial Cancer

Endometrial cancer is the most common gynecological malignancy affecting women's health. About 15% of the patients will have local late disease (stage III) with high risk of recurrence and tumor related mortality.

cancer
neutrophil count
adjuvant
stage iii endometrial cancer
platelet count
  • 0 views
  • 19 Feb, 2024
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer ALCHEMIST Chemo-IO Study

This phase III ALCHEMIST trial compares the addition of pembrolizumab to usual chemotherapy versus usual chemotherapy for the treatment of stage IB, II, or IIIA non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the …

pembrolizumab
cisplatin/gemcitabine
squamous cell carcinoma
gemcitabine
lung carcinoma
  • 0 views
  • 19 Feb, 2024
Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients

This study aimed to investigate the effect of low-dose (100 mg) asprin on the prevention of gastric cancer in the early gastric cancer patients with negative H. pylori status who underwent endoscopic submucosal dissection.

cancer
aspirin
cancer treatment
prevention of gastric cancer
endoscopic submucosal dissection
  • 0 views
  • 19 Feb, 2024
Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer

This is a large, prospective, single-arm cohort study of transvaginal ultrasonographic screening for ovarian cancer in intermediate to high-risk women from Kentucky. Detection of ovarian malignancy often occurs subsequent to the initial transvaginal sonography (TVS) screen therefore, it is important to offer continued screening to study participants based on our …

cancer
ovarian cancer
transvaginal ultrasound
hysterectomy
ovarian cancer screening
  • 0 views
  • 19 Feb, 2024
Evaluate the Efficacy Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females

This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 9-valent Human Papillomavirus (Types 6, 11, 16, 18,31,33,45,52 and 58) Recombinant Vaccine (Hansenula Polymorpha) in Chinese Female Subjects Aged 20-45 Years .

cancer
oral contraceptives
emergency contraception
recombinant vaccine
flushed skin
  • 0 views
  • 19 Feb, 2024
Reduced vs Conventional Dosage Intensity-modulated Radiotherapy for Chemotherapy-sensitive Stage II-III Nasopharyngeal Carcinoma

Through multicenter, open-label, randomised clinical trials, we intend to demonstrate that radiotherapy with reduced dose could significantly reduce the incidence of radiotherapy toxicities, improve the quality of life of patients while ensuring the tumor control rates for NPC patients staged as II-III who are sensitive to induction chemotherapy (imaging evaluation …

intensity-modulated radiotherapy
induction chemotherapy
intensity-modulated radiation therapy
epstein-barr virus dna
ebv dna
  • 6 views
  • 19 Feb, 2024
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)

This study is designed to assess the antitumor efficacy and safety of pembrolizumab in combination with chemoradiotherapy (CRT) versus CRT alone in participants with muscle-invasive bladder cancer (MIBC). The primary hypothesis is that pembrolizumab + chemoradiotherapy is superior to placebo + chemoradiotherapy with respect to bladder intact event-free survival.

cancer
mitomycin
bladder cancer
pembrolizumab
fluorouracil
  • 0 views
  • 19 Feb, 2024
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with concurrent chemoradiation therapy followed by either pembrolizumab with olaparib placebo (Arm 1) or with olaparib (Arm 2) compared to concurrent chemoradiation therapy followed by durvalumab (Arm 3) in participants with unresectable, locally advanced …

small cell lung cancer
cancer
carboplatin
pembrolizumab
lung neoplasm
  • 0 views
  • 19 Feb, 2024