Found 2392 clinical trials
Inspiratory Muscle Training Versus Calf Muscle on Venous Function
While the control group will receive only compression therapy, the inspiratory exercise group will apply inspiratory muscle training consisted of strengthening exercise in addition to compression therapy; kalf muscle exercise group will apply strengthening exercise for calf muscle in addition to compression therapy for 2 days/week with physiotherapist and 3 …
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- 19 Feb, 2024
- 1 location
Molecular Imaging of Prostate Cancer Using Radiofluorinated PSMA Ligand
Additionally, if the patient undergoes a biopsy as standard of care, image features will correlate directly with histopathological findings.Validation of this radiotracer can potentially lead to its use as a standard of care for future imaging and improve diagnosis and treatment guidance.This drug is not approved by the Food and …
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- 19 Feb, 2024
- 1 location
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
Participants are assigned to one of 8 cohorts based on their primary tumour type: breast, lung, gastrointestinal (GI), primary unknown, genitourinary (GU), sarcoma, gynecological, and 'other' cancer types. Participants in all cohorts will receive the same dose of atezolizumab (1200 mg every 3 weeks). In the first stage for each …
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- 19 Feb, 2024
- 1 location
The Acute Effects of Pragmatic Manual Therapy on the Range of Motion of Shoulder Joint
The purpose of this study is to evaluate the effects of each individual factor and combination of all on the range of motion of shoulder joint in healthy subjects and subjects with restricted range of motion of shoulder joint respectively.
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- 19 Feb, 2024
- 1 location
Neoadjuvant mFOLFOXIRI Plus Bevacizumab With Selective Radiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer
A small single-center phase II pilot trial treated patients with stage II or III rectal cancer with induction FOLFOX/bevacizumab chemotherapy followed by CRT only in those with stable or progressive disease and resection in all patients. All 32 of the participants had an R0 resection, and the 4-year DFS was …
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- 19 Feb, 2024
- 1 location
Intervention for Fluency Difficulty
The focus of the study is to identify children with word-finding difficulty and other speech and communication difficulties such as stuttering, a procedure referred to as screening. Ideally, investigators want to screen all children in the reception classes in the schools with which investigators work. The procedures were designed so …
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- 19 Feb, 2024
- 1 location
Efficacy of Different Toothbrushes and Hygiene Regimen
Two calibrated and blinded examiners (Cohen Kappa 85%) will evaluate the gingival condition using the visible plaque indices, a simplified oral hygiene index - IHOS and gingival bleeding index, with the aid of a WHO probe. For the evaluation of halitosis levels, all individuals will respond to a questionnaire regarding …
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- 19 Feb, 2024
- 1 location
Ketamine Analgesia in Third Molar Surgery
New knowledge of the mechanisms of pain increases the opportunities for individual and safe pain relief. Day case surgery is performed in all operating specialties, this might affects many patients nationally and internationally.
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- 19 Feb, 2024
- 1 location
Effects of a Multimodal Exercise Program on Physical Performance and Muscle Function in Middle-aged Patients With T2DM
Intervention Group: Participants will receive the same leaflet along with a "Diabetes and Muscle Health Handbook" and will take part in a 12-week multimodal exercise program.Assessments: All participants will be assessed at baseline, week 6, and week 12.Outcome MeasuresPrimary Outcomes:o Physical Function: Short Physical Performance Battery (SPPB), Five-Times Sit-to-Stand Test …
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- 02 Dec, 2025
- 3 locations
Personalized Extended Interval Dosing of Natalizumab in Relapsing Remitting Multiple Sclerosis
Study design: Prospective national phase IV natalizumab cohort study. Study population: All patients, aged 18 years or older, who are currently treated with natalizumab in the Netherlands for RRMS, with a minimum of 6 consecutive infusions.
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- 19 Feb, 2024
- 15 locations