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Found 18 clinical trials
A Study of ASTX030 (Cedazuridine in Combination With Azacitidine) in MDS CMML or AML

Study ASTX030-01 is designed to move efficiently from Phase 1 to Phase 3. Phase 1 consists of an open-label Dose Escalation Stage (Stage A) using multiple cohorts at escalating dose levels of oral cedazuridine and azacitidine (only one study drug will be escalated at a time) followed by a Dose …

myelodysplastic/myeloproliferative neoplasm
cedazuridine
myelodysplastic syndrome
immunosuppression
major surgery
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  • 19 Feb, 2024
CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

This phase II trial studies how well liposome-encapsulated daunorubicin-cytarabine (CPX-351) works in treating patients with secondary acute myeloid leukemia who are younger than 60 years old. Drugs used in chemotherapy, such as CPX-351, work in different ways to stop the growth of cancer cells, either by killing the cells, by …

myelodysplastic syndrome
treatment related acute myeloid leukemia
myelodysplasia
daunorubicin
myelodysplastic syndrome acute myeloid leukemia
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  • 19 Feb, 2024
Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

This phase II trial studies how well decitabine with ruxolitinib or fedratinib works before hematopoietic stem cell transplant in treating patients with accelerated/blast phase myeloproliferative neoplasms (tumors). Drugs used in chemotherapy, such as decitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, …

myeloproliferative disorder
polycythemia
white blood cell count
myelofibrosis
decitabine
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  • 19 Feb, 2024
Cross-sectoral Collaboration in Multidisciplinary Treatment of Trauma-affected Refugees

INTRODUCTION Trauma-affected refugees are at high risk of developing mental health problems including post-traumatic stress disorder (PTSD) and depression. In addition to traumatic stress, refugees are furthermore subject to a range of post-migration stressors e.g. unemployment, poor finances and language difficulties. These stressors can moderate or exacerbate mental health outcomes …

depression
stress disorders
psychological trauma
post-traumatic stress disorder
cognitive therapy
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  • 19 Feb, 2024
Advanced Translational Research on Childhood Leukemia

Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of <50%, which is unlikely to be boosted by intensification of standard chemotherapy due to overwhelming toxicity. The advent of effective and safe targeted …

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  • 19 Feb, 2024
AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration

In this study, the investigators will explore the feasibility of ex vivo drug screening to predict sensitivity to chemotherapy resistance and to identify novel synergy between chemotherapies.

gemtuzumab
idarubicin
midostaurin
aml/mds
myelodysplastic syndrome
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  • 19 Feb, 2024
Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers

This pilot research trial studies the antibody response to high-dose seasonal influenza vaccination in patients with myeloid malignancy receiving chemotherapy and healthy volunteers. Evaluating antibody response to high-dose seasonal influenza vaccine may serve as a basis for vaccine recommendations in patients with myeloid malignancies and provide insights into the status …

cancer
influenza
myelodysplastic syndrome
antibody response
influenza vaccination
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  • 19 Feb, 2024
Dentists' Perception Regarding the Use of Social Media for Professional Purpose

Social Media has significant influence in everyone's life. Social media is considered as one of the biggest revolution in the information technology. It empowers the users to express and share their thoughts, opinions, views, and content to the rest of the world. Entire world id just a click away from …

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  • 19 Feb, 2024