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Found 198 clinical trials
A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

  • To evaluate the effect of venglustat on the lens by ophthalmological examination (Stages 1 and 2).
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    cyst
    ophthalmological examination
    autosomal dominant
    urine osmolality
    fatigue
    • 0 views
    • 19 Feb, 2024
    • 81 locations
    Study of a Novel Multicomponent Meningococcal Group B Vaccine When Given Alone or With Other Licensed Vaccines in Adults, Adolescents, Toddlers and Infants

    Primary Objective:

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  • To describe the safety profile of the SP MenB vaccine formulations and the 2 licensed MenB comparator vaccines in healthy adults, adolescents, toddlers and infants, when administered alone (Stages 1-4) or concomitantly with MenQuadfiTM (MenACYW conjugate vaccine) (for Stages 2-4 only), and with age-appropriated routine pediatric vaccines …

    Accepts healthy volunteers
    • 0 views
    • 19 Feb, 2024
    • 22 locations
    Study of a Novel Multicomponent Meningococcal Group B Vaccine When Given Alone or With Other Licensed Vaccines in Adults, Adolescents, Toddlers and Infants

    Primary Objective:
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  • To describe the safety profile of the SP MenB vaccine formulations and the 2 licensed MenB comparator vaccines in healthy adults, adolescents, toddlers and infants, when administered alone (Stages 1-4) or concomitantly with MenQuadfiTM (MenACYW conjugate vaccine) (for Stages 2-4 only), and with age-appropriated routine pediatric vaccines …

    Accepts healthy volunteers
    • 0 views
    • 19 Feb, 2024
    • 21 locations
    Genetic Characteristics of Metastatic Breast Cancer Patients

  • At disease progression after 1st line treatment for MBC, blood sample (20cc) will be obtained (tissue; optional)
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    (2) WES, RNASeq, ctDNA, Exosome

    <ul>
  • We will analyze genomic characteritics using WES, RNASeq, ctDNA, Exosome.
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    stage iv breast cancer
    cancer
    breast cancer
    • 0 views
    • 19 Feb, 2024
    Safety Pharmacokinetics and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation

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    Secondary Objectives:

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  • Phase 2: To characterize the safety profile of isatuximab in kidney transplant candidates.

    chronic kidney disease
    kidney transplant
    nephropathy
    sar650984
    diphenhydramine
    • 0 views
    • 19 Feb, 2024
    • 2 locations
    MTD Safety and Efficacy of NYH817G and NYH100P in Monotherapy and Combination in Patients With Advanced Solid Tumors

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    • 0 views
    • 19 Feb, 2024
    Dose De-escalation Study of the PI3k Alpha/Delta Inhibitor Copanlisib Given in Combination With the Immunotherapeutic Agents Nivolumab and Rituximab in Patients With Relapsed/Refractory Indolent Lymphoma

    Patients with relapsed or refractory follicular or marginal zone lymphoma who have received at least one prior line of therapy will receive

    <ul>
  • Copanlisib IV: day 1, 8, 15 every 28 days
  • Nivolumab IV: Cycle 1 days 1 and 15; then day 1 only
  • Rituximab IV: Cycle 1 days …

    angina
    investigational treatment
    alcoholic cirrhosis
    cyp3a4 inhibitors
    hba1c
    • 0 views
    • 19 Feb, 2024
    Descriptive and Evaluation Study of the Use of Pulmonary Ultrasound in the Initial Management of Pregnant Women in the Context of COVID-19

    Objectives :

    Primary objective:

    To describe the lung ultrasound lesions in pregnant women in case of suspected or confirmed COVID-19

    Secondary objectives:

    <ul>
  • To compare the lung ultrasound lesions with chest Computed Tomography -scanner (CT-Scan) lesions
  • To evaluate the performances of …

    • 0 views
    • 19 Feb, 2024
    A Multinational Randomized Double-blind Placebo-controlled Study to Assess the Efficacy Pharmacodynamics Pharmacokinetics and Safety of Venglustat in Late-onset GM2

    Primary Objectives:

    Primary population (adult participants with late-onset GM2 gangliosidosis): To assess the efficacy and pharmacodynamics (PD) of daily oral dosing of venglustat when administered over a 104-week period

    Secondary population (participants with juvenile/adolescent late-onset GM2 gangliosidosis, GM1 gangliosidosis, saposin C deficiency, sialidosis type 1 or …

    • 0 views
    • 19 Feb, 2024
    • 2 locations
    Multicenter Perspective Study: Clinical Evaluation of the Persona MC With Preservation or Sacrifice of the PCL

    Primary endpoint

    -Evaluation of the survival of the implant after 5 years of follow-up

    Secondary endpoints

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  • Evaluation of the survival of the implant at 10 years of follow up.
  • Evaluation of clinical and radiographic outcomes in Italian patients undergoing total knee replacement …

    avascular necrosis
    knee arthroplasty
    patellectomy
    arthritis
    polyarthritis
    • 0 views
    • 19 Feb, 2024