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Found 40 clinical trials
Cognitive Training and Brain Stimulation in Prodromal Alzheimer's Disease

The aim of this study is to investigate whether a tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in individuals with prodromal Alzheimer's disease.

brain stimulation
cognitive impairment
transcranial direct current stimulation
mild cognitive impairment
prodromal alzheimer's disease
  • 0 views
  • 19 Feb, 2024
An Advance Care Planning Programme for Persons With Early Stage Dementia or Mild Cognitive Impairment in the Community

Advance care planning (ACP) has been widely advocated for persons with early stage dementia (PWEDs) and persons with mild cognitive impairment (MCI). This proposed study attempts to promote the uptake of ACP for this population and their family caregivers in the community and to examine the effects of an ACP …

dementia
mild cognitive impairment
cognitive impairment
  • 0 views
  • 19 Feb, 2024
A Study to Evaluate the Safety Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With Early Alzheimer's Disease

This study is a multicenter, double blind, randomized, placebo-controlled study to evaluate the safety, tolerability and immunogenicity of different doses, regimens and combinations of Tau targeted vaccines in participants with early Alzheimer's Disease.

dementia
acetylcholinesterase inhibitor
cognitive impairment
mental state examination
memantine
  • 0 views
  • 19 Feb, 2024
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study

Today in elderly tooth loss and loss of oral function is widespread, but it is an underexplored modifiable risk factor potentially contributing to the development of dementia. In this interventional study we want to investigate a "cause-effect" relationship between mastication and cognition in humans. A total of eighty (80) participants, …

dementia
mental state examination
prosthetic rehabilitation
mini-mental state examination
cognitive changes
  • 0 views
  • 19 Feb, 2024
Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

This early phase I trial studies the feasibility of giving memantine for the reduction of cognitive impairment after radiation therapy in pediatric patients with central nervous system tumors. Memantine may reduce the effects of radiation therapy on memory and thinking.

effects of radiation therapy
direct bilirubin
cognitive impairment
memantine
cancer
  • 0 views
  • 19 Feb, 2024
Evaluation of a Virtual Reality Tool for Identifying the Cognitive Functions of the Right Hemisphere in Patients With Glioma -TANGO

Evaluate the diagnostic performance of a virtual reality application to detect the presence of cognitive impairment of the non-dominant hemisphere in patients with glioma

cognitive impairment
  • 0 views
  • 19 Feb, 2024
Exergaming in People With Major Neurocognitive Disorder

This randomized controlled trial explores the efficacy of an 8-week standing exergaming program in people with major neurocognitive disorder (MNCD) residing in long-term care facilities.

dementia
mental state examination
neurocognitive disorders
mini-mental state examination
parkinson's disease
  • 0 views
  • 19 Feb, 2024
Effects of Transcranial Direct Current Stimulation Associated With Cognitive Training in Alzheimer's Disease

Cognitive training (TCog) has similarly shown excellent results in the treatment of cognitive deficits due to AD. Thus, the present study aims to investigate when (before, during or after) the tDCS should be applied to potentiate the effects of TCog in people with AD by comparing four protocols of application …

mental state examination
cognitive disorder
mini-mental state examination
psychiatric disorder
behavioral symptoms
  • 0 views
  • 19 Feb, 2024
PET Imaging of Cyclooxygenases in Dementia

Background About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective To learn if two new radiolabeled drugs, [11C]PS13 …

dementia
huntington's disease
neurological examination
cognitive impairment
huntington's chorea
  • 0 views
  • 19 Feb, 2024
The TARGET-EFT Trial

Randomized clinical trial to determine whether a multicomponent intervention will lead to improvements in mobility, self-care, mood, pain, and physical activity among frail and pre-frail older adults (as measured with the Essential Frailty Toolset; EFT) hospitalized for an acute cardiovascular illness.

anemia
malnutrition
  • 0 views
  • 19 Feb, 2024