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Found 208 clinical trials
Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.

Brief summary: The objective of this study is to compare two different ablation strategies in participants with persistent atrial fibrillation and fibrotic areas in the left atrium. The participant will be randomized to pulmonary vein isolation or pulmonary vein isolation plus ablation of fibrotic areas.

atrial fibrillation
fibrillation
catheter ablation
pulmonary vein isolation
radiofrequency ablation
  • 0 views
  • 19 Feb, 2024
Effectiveness and Acceptability of MINDFULNESS by Smartphone for Patients With Chronic Migraine and Medication Overuse

Chronic Migraine is a disabling condition that affects the 2% of migraine population. It is often associated with medication overuse that makes this condition very difficult to treat. The literature of the last decades confirm the efficacy of withdrawal for patients with medication overuse but it is also confirmed that …

chronic migraine
therapeutic process
analgesia
migraine
  • 0 views
  • 19 Feb, 2024
2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation

The proposed studies will test this hypothesis by randomizing patients with AF to 2-HOBA or placebo 7 days prior to AF ablation to allow 2-HOBA to reach steady-state levels. We hypothesize that tissue injury from AF ablation causes a large release of ROS that react with lipids to generate IsoLGs …

fibrillation
  • 0 views
  • 19 Feb, 2024
A Study of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

The purpose of this study is to evaluate the safety of Guselkumab in participants with Crohn's disease.

ileocolitis
stomach pain
colitis
ileitis
endoscopy
  • 0 views
  • 19 Feb, 2024
AQI and Childhood Asthma: an Intervention

This is a small pilot prospective intervention trial in children with asthma who will be randomized to receive either (A) Air Quality Index (AQI) education + an asthma action plan (control) or (B) AQI education + an asthma action plan which contains AQI behavioral recommendations + demonstrate ability to navigate …

asthma
childhood asthma
persistent asthma
  • 42 views
  • 19 Feb, 2024
First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL

Primary Objective: To determine the maximum tolerated dose (MTD) of SAR442257 administered as a single agent in patients with relapsed and refractory multiple myeloma (RRMM) and refractory non-Hodgkin lymphoma (RR-NHL), and determine the recommended Phase 2 dose (RP2D) Secondary Objectives: To characterize the safety profile of SAR442257 To characterize the …

hodgkin's disease
lymphoma
cutaneous t-cell lymphoma
diffuse large b-cell lymphoma
multiple myeloma
  • 0 views
  • 19 Feb, 2024
  • 5 locations
Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation With Heart Failure

The combination of atrial fibrillation (AF) and heart failure (HF) is common and implies a poor prognosis. Pulmonary vein isolation is an established method for the treatment of symptomatic AF in patients with normal heart function and has been shown to be more effective than drug therapy. Recently, radiofrequency ablation …

pulmonary vein isolation
atrial fibrillation
radiofrequency ablation
persistent atrial fibrillation
heart failure
  • 0 views
  • 19 Feb, 2024
Left Atrial Posterior Wall Additional Isolation for Persistent Atrial Fibrillation Trial

The purpose for this study is to determine whether left posterior wall isolation (PWI) in addition to pulmonary vein isolation (PVI) is effective as ablation strategy for persistent atrial fibrillation (AF).

atrial fibrillation
fibrillation
cardiac ablation
catheter ablation
pulmonary vein isolation
  • 0 views
  • 19 Feb, 2024
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Background Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or reduces metastasis. Researchers hope a new drug can help. It stops cancer cells from growing and spreading further and possibly shrink cancer lesions in distant …

electroencephalogram
renal function
blood transfusion
pediatric
blood tests
  • 0 views
  • 19 Feb, 2024
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease. T2D and heart disease share many common risk factors such as aging, obesity and unhealthy lifestyle. Paradoxically however, while lowering blood LDL, commonly known as "bad cholesterol", …

omega-3 fatty acids
fish oils
diabetes
insulin
insulin sensitivity/resistance
  • 0 views
  • 19 Feb, 2024