Found 1914 clinical trials
Open-label Study to Determine the Maximum Tolerated Dose of DSG3-CAART in Mucosal-dominant PV Patients (mPV)
This phase 1 study is being conducted to find the maximum tolerated dose and optimal fractionated infusion schedule of an investigational cell therapy, DSG3-CAART, that can be given to patients with mPV who are inadequately managed by standard therapies. DSG3-CAART may potentially lead to complete and durable remission of disease.
- 0 views
- 19 Feb, 2024
- 1 location
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP)
The investigators hypothesize that apomorphine pump is superior in terms of positive impact on quality of life (QoL) to oral medical therapy alone at a relatively early stage of PD, before the appearance of severe disabling motor complications thus favoring the maintain of patients' social and occupational status with a …
- 0 views
- 19 Feb, 2024
- 21 locations
Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Young Adults
The purpose of the CliniMACS TCR-Biotin System and CliniMACS CD19 is to improve the safety and efficacy of allogeneic HLA-partially matched related or unrelated donors HSCT when no matched donors are available, to treat malignant and nonmalignant disorders for which HSCT is the recommended best available therapy. Initially this device …
- 0 views
- 19 Feb, 2024
- 1 location
Teaching Novel Values-Based Skills to Improve Long-Term Weight Loss
This NIDDK funded R01 project is a randomized controlled clinical trial to compare the efficacy of an intervention based on Acceptance and Commitment Therapy (ACT) and a Self-Regulation (SR) intervention on weight loss maintenance over a 30-month period. All participants will first complete a well-validated online weight loss intervention (months …
- 0 views
- 19 Feb, 2024
- 1 location
PHP and Immunotherapy in Metastasized UM
It usually disseminates rapidly throughout the body, most commonly to the liver and lungs. In this study a combination therapy with immunotherapy (ipilimumab with nivolumab) and chemotherapy (melphalan) will be assessed for the treatment of disseminated uveal melanoma.
- 0 views
- 19 Feb, 2024
- 1 location
Targeting CD276 (B7-H3) Positive Solid Tumors by 4SCAR-276
Patients with refractory and/or recurrent solid tumor have poor prognosis despite complex multimodel therapy and therefore, novel approaches are urgently needed. This study attempts to treat these diseases using T cells genetically modified with a 4th generation lentiviral chimeric antigen receptor (4SCAR fused with an inducible apoptotic caspase 9 domain) …
- 0 views
- 19 Feb, 2024
- 3 locations
Optimizing Quality of Life in Women Living With Metastatic Breast Cancer
In the first phase of this study, we conducted patient focus groups to gather information about the unique challenges of living with MBC and what kinds of support women would like to receive in a tailored Acceptance and Commitment Therapy (ACT) intervention. In the second phase of the study, we …
- 0 views
- 19 Feb, 2024
- 1 location
The Positively Quit Trial for Smoking Cessation
People in both groups will receive brief advice to quit and an offer of nicotine replacement therapy patches (NRT), as well as 12 videoconferencing group sessions. We will measure smoking behavior over a one year period and compare smoking rates for the treatment condition against AMC to see if the …
- 0 views
- 19 Feb, 2024
- 1 location
Validation of Standardized Test Protocols to Assess the Impact of Visual Pathologies in Daily Life Activities
This tool can be used to measure a therapeutic benefit for new treatments (like gene therapy, retinal implants, intra vitreous injections ) for visual loss patients.
- 0 views
- 19 Feb, 2024
- 1 location
The Effect of Intravenous Ketamine on Non Suicidal Self Injuries.
This behavior is related to unbearable internal stress, thoughts, or mental pain, which NSSI assists in dismantling. To date, there is no generally approved therapy that assists in lowering NSSI. Ketamine is a sedative drug, presently at the focus of psychopharmacologic research, which was found to improve depression, when taken …
- 0 views
- 19 Feb, 2024
- 1 location