Found 1727 clinical trials
Multi-Center Adolescent Clavicle Fracture Trial: Operative vs. Non-Operative Treatment
Investigators from eight tertiary care, level 1 pediatric trauma centers have developed a protocol for the establishment of a formal, prospective multi-center adolescent clavicle registry, with designs for standardized radiographic assessment and the prospective collection of validated outcome measures and complications data, for all patients, ages 10-18, treated for clavicle …
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- 19 Feb, 2024
- 1 location
Interruptions Teamwork Stress and Patient Outcomes in the Operating Room
Selected surgeries are evaluated by a trained observer and the interruptions and distractions in the course of the surgery are observed with a standardized tool. In addition, non-technical skills of the OR team are recorded: all members of the OR team will complete a short standardized questionnaire that measures mental …
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- 19 Feb, 2024
- 1 location
Observational Study in Diagnosed Patients COVID-19 Supported on an Outpatient Basis. (COVID-PSL)
Given the novelty of this infection, several questions remain: What are all the symptoms that can be contracted by a COVID-19 patient? Are there clinical forms not described? What is the evolutionary profile, the healing time of this disease in patients treated on an outpatient basis?
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- 19 Feb, 2024
- 1 location
Viral Excretion in Contact Subjects at High/Moderate Risk of Coronavirus 2019-nCoV Infection. COVID-19.
In most European countries, healthcare workers adopt this second option. In all cases, it is most often recommended that contact persons monitor their state of health and communicate it to the persons dedicated to this action.
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- 19 Feb, 2024
- 17 locations
Lung Ultrasound Score in Covid 19 Infectious Disease in Critical Care (LUS-COVID19)
In Critical Care 2016, it has been showed that ultrasound allowed with neat precisions, to predict severe ARDS patient response to the prone position, all-cause. Another researchers team found a good correlation between lung ultrasound, the SOFA, APACHE II, CPIS score, and patient mortality.
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- 19 Feb, 2024
- 1 location
Biomarkers in Rheumatoid Arthritis Treated With Anti-interleukin-6 Therapy
Investigators thus hypothesized that experimental biomarker levels will still be increased at D15, contrary to usual biomarkers dependant on IL-6 which will be normal whereas rheumatoid arthritis is still active based on usual radiological and clinical criteria, and that all biomarkers will be normal a W24.
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- 19 Feb, 2024
- 1 location
Clinical Database of Safe Personalized Adjuvant Breast Radiotherapy Based on Individual Radiosensitivity
Hypofractionation has been adapted to breast cancer radiotherapy. Overall, all recent clinical trials [13, 14] showed only few late effects when hypofractionation was delivered to the whole breast (WB). These results reinforce the need of patients' selection using the NovaGray Breast test.
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- 19 Feb, 2024
- 1 location
Cetuximab Therapeutic Drug Monitoring in Squamous Cell Carcinoma Head and Neck Cancer Patients: Determination of the Predictive Value Exposure Levels Through a Single Arm Multicentric Study
Determining cetuximab plasma clearance requires sophisticated PK modeling using population approaches, thus making it difficult to implement in routine clinical practice. In addition, all the preliminary studies with cetuximab were based upon Elisa determination of cetuximab plasma levels, an analytical method that fails to meet the requirements of daily practice …
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- 19 Feb, 2024
- 1 location
Cardiovascular Function and Ribavirin PK/PD in Lassa Fever in Lassa Fever
Arenaviruses are included in the World Health Organisation R&D Blueprint list of high priority pathogens, since this virus group includes several epidemic-prone highly pathogenic viruses for which there are inadequate diagnostic, therapeutic, and preventative interventions. Junin, Machupo, Guanarito, Sabia, Lujo, and Lassa virus can all cause a viral haemorrhagic fever …
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- 19 Feb, 2024
- 1 location
Intestinal Flora Research Plan for Critically Ill Patients
Especially for acute stress, severe stress, the use of broad-spectrum antibiotics, vasoconstrictors and opioids, intestinal ischemia/reperfusion injury, epithelial cell apoptosis, barrier integrity destruction, gastrointestinal Changes in the motility of the tract, lack of nutrients in the intestinal cavity, etc. All those can lead to rapid changes in the intestinal flora, …
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- 19 Feb, 2024
- 1 location