Found 166 clinical trials
RASopathy Biorepository
The RASopathies are a group of developmental disorders caused by genetic changes in the genes that compose the Ras/mitogen activated protein kinase (MAPK) pathway. New RASopathies are being diagnosed frequently. This pathway is essential in the regulation of the cell cycle and the determination of cell function. Thus, appropriate function …
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- 19 Feb, 2024
- 1 location
Investigation of the Respiratory Profile of Patients With Obstructive Pulmonary Disease (ASTHMA, COPD) (OPTIPULM)
The study also compares results across different flow rates and device resistances, aiming to identify the device with the highest modelled lung deposition for each patient.Understanding and Improving Inhalation Therapy in Lung Disease The OPTIPULM study looks at how well inhaled medications reach the lungs of people living with asthma …
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- 12 May, 2025
The Real World Study of Neoadjuvant Immunotherapy in Early Stage NSCLC in China
Several published clinical trials have shown the superiority of immunotherapy in neoadjuvant setting. Here we conducted this real world study to see whether neoadjuvant immunotherapy would bring MPR and survival benefits in NSCLC, for example, single agent immunotherapy or immunotherapy combination with chemotherapy. Furthermore biomarker analysis would be also performed …
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- 19 Feb, 2024
- 1 location
Classification of Benign and Malignant Lung Nodules Based on CT Raw Data
The employ of medical images combined with deep neural networks to assist in clinical diagnosis, therapeutic effect, and prognosis prediction is nowadays a hotspot. However, all the existing methods are designed based on the reconstructed medical images rather than the lossless raw data. Considering that medical images are intended for …
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- 19 Feb, 2024
- 1 location
Lung Ultrasound in COVID-19 Patients
To assess the prognostic performance of an early global LUS score with respect to the mortality in ICU and duration of ventilation.
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- 19 Feb, 2024
- 1 location
Immunotherapy in Lung Cancer: Treatment After IO Cessation.
Immunotherapy is now a standard of care for first-line and eventually salvage therapy in patients with stage IV NSCLC and as adjuvant after RT-CT for stage III NSCLC. The aim of the study is determining the therapeutic landscape and the reason for immunotherapy cessation.
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- 19 Feb, 2024
- 5 locations
Thromboembolic Events in Severe COVID-19 Patients
The main objective of this study is to describe the incidence of thromboembolic events in a population of patients hospitalized in intensive care units in France for severe COVID-19. The secondary objective of this study is to describe the evolution of hemostasis parameters during the first two weeks of intensive …
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- 19 Feb, 2024
- 1 location
Sequelae of Sars-CoV-2 Infections
By the end of 2019 a new coronavirus, named SARS-CoV-2, was discovered in patients with pneumonia in Wuhan, China. In the following weeks and months the virus spread globally, having a tremendous impact on global health and economy. To date, no vaccine or therapy is available. Severe courses of the …
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- 19 Feb, 2024
- 1 location
Lung Function Exercise Capacity and Health-Related Quality of Life After Severe COVID-19
The medium and long-term impact in survivors of severe COVID-19 on lung function, exercise capacity and health-related quality of life remains to be determined.
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- 19 Feb, 2024
- 5 locations
Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer
The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients. Through controllable cell-material interaction, this project has the intention to develop an alternative tool for both early diagnosis and accurate prognosis in cancer …
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- 19 Feb, 2024
- 1 location