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Found 208 clinical trials
Pediatric Caudal Injection Volume on Optic Nerve Sheath Diameter and Cerebral Oxygenation

Caudal anesthesia is a commonly used neuraxial anesthesia method for children. Injection of a certain volume of fluid into the epidural space for cauda anesthesia may push some cerebrospinal fluid towards the head, which may lead to mild increase of pressures inside the head. Such mild changes are compensated well …

caudal injection
pediatric
elective surgery
optic nerve
  • 0 views
  • 19 Feb, 2024
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia"

This is a Phase 1-2, multicenter, international, single-arm, open-label study designed to identify a recommended dose of bosutinib administered orally once daily in pediatric patients with newly diagnosed chronic phase Ph+ CML (ND CML) and pediatric patients with Ph+CML who have received at least one prior TKI therapy (R/I CML), …

blastic phase chronic myeloid leukemia
philadelphia chromosome
differentiation therapy
molecular diagnosis
major surgery
  • 0 views
  • 19 Feb, 2024
Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

This early phase I trial studies the feasibility of giving memantine for the reduction of cognitive impairment after radiation therapy in pediatric patients with central nervous system tumors. Memantine may reduce the effects of radiation therapy on memory and thinking.

cancer
cognitive impairment
direct bilirubin
memantine
effects of radiation therapy
  • 0 views
  • 19 Feb, 2024
Tipifarnib for the Treatment of Advanced Solid Tumors Lymphoma or Histiocytic Disorders With HRAS Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have HRAS genetic alterations.

cns tumor
hodgkin's disease
pleural effusion
myelosuppressive chemotherapy
refractory non-hodgkin lymphoma
  • 0 views
  • 19 Feb, 2024
Study to Evaluate Patients With Cerebrotendinous Xanthomatosis

The study is made up of two cohorts: a randomized double-blind crossover (placebo withdrawal with rescue) study among patients 16 years of age (adult cohort) and an open-label dose titration study among pediatric patients 1 month and <16 years of age (pediatric cohort)

  • 0 views
  • 19 Feb, 2024
Ultrasound vs. Auscultation for Optimal Depth of the Cuffless RAE Tube

The aim of this study is to compare the ultrasound-guidance versus auscultation to confirm optimal insertion depth of the cuffless oral Ring-Adair-Elwyn (RAE) endotracheal tube in pediatric patients undergoing general anesthesia.

intubation
auscultation
pediatric
anesthesia
  • 0 views
  • 19 Feb, 2024
Phase 2 Trial of CD19 Redirected Autologous T Cells

This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very high risk KMT2A B-ALL (Cohort C), and in patients with central nervous system (CNS) relapse who did not receive …

  • 0 views
  • 19 Feb, 2024
A Study of Itolizumab (EQ001) to Evaluate the Safety Tolerability PK PD and Clinical Activity in Uncontrolled Asthma

This is a multi-center study to evaluate the safety, tolerability, PK, PD, and clinical activity of itolizumab (EQ001) in subjects with moderate-to-severe asthma.

forced expiratory volume
fluticasone
anticholinergics
bronchial provocation test
albuterol
  • 0 views
  • 20 Sep, 2024
  • 4 locations
A Randomized Controlled Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma  

The purpose of this study is to assess the safety and tolerability of a 6-week Inspiratory Muscle Training and cardiovascular exercise training program in children and adolescents with asthma. To also determine the efficacy of inspiratory muscle training and exercise in increasing respiratory muscle strength and endurance, and to explore …

persistent asthma
breathing exercises
dyspnea
  • 0 views
  • 20 Sep, 2024
  • 1 location
Implementing a Guidelines-Based M-Health Intervention for High Risk Asthma Patients

            The goal of this research study is to test how good an app is in making asthma easier to manage for 372 adolescents/young adults. The app is a mobile version of the asthma action plan. mAAP

Accepts healthy volunteers
  • 8 views
  • 20 Sep, 2024
  • 1 location