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Found 1304 clinical trials
Phase I Study in Advanced Malignancies

RDT aims to take advantage of the relatively safer toxicity profiles of both lower dose radiation therapy and systemic ALA to treat non-superficial lesions in a manner similar to photodynamic therapy. The doses of radiation administered in this study will be lower than those typically used to treat cancer. However, …

serum bilirubin
neutrophil count
alopecia
major surgery
hair thinning
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  • 19 Feb, 2024
The Influence of a Perturbation Training on Balance Recovery of Old Adults: a Randomized Controlled Trial

We hypothesize that response to an unexpected loss of balance is the balance responses will be improved in both training methods, but more in the random training method. We also hypothesize that brain function as seen in MRI will be improved in both training methods, more in the random training …

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  • 19 Feb, 2024
Injections of Glutamic Acid Decarboxylase (GAD) for LADA Type of Diabetes

This study will evaluate the effects of 3 intra-nodal injections of GAD-alum (Diamyd), together with oral vitamin D supplementation. Safety and feasibility of the treatment will be evaluated and also effects on the immune system and on the preservation of endogenous insulin production.

metformin
vitamin d
diabetes
vitamin d supplementation
ergocalciferol
  • 0 views
  • 19 Feb, 2024
AAV Gene Therapy Study for Subjects With PKU

Participants will receive a single administration of BMN 307 and will be followed for safety and efficacy.

gene therapy
deficiency
  • 0 views
  • 19 Feb, 2024
CCCG Relapsed Acute Lymphoblastic Leukemia 2017 Study in Children

New agents will be added aiming at improving survival outcome. Study of adding anti-CD20 antibody (rituximab) with chemotherapy: CD20 is found to be expressed in 40-50% of B-lineage ALL, and rituximab has been studied in adult ALL with superior survival (75% vs 47%,).

testicular
acute lymphoblastic leukemia
rituximab
flow cytometry
bortezomib injection
  • 0 views
  • 19 Feb, 2024
89Zr-atezolizumab PET Scan and Lobular Breast Cancer

All patients will undergo two Zirconium-89 (89Zr)-atezolizumab positron emission tomography (PET) scans, one at baseline and one after two doses carboplatin induction treatment. The 89Zr-atezolizumab PET scan will be performed 4 days after tracer injection. Procedures within the ImaGelato study will be completed after the two 89Zr-atezolizumab PET scans, but …

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  • 19 Feb, 2024
The Effect of Intravenous Ketamine on Non Suicidal Self Injuries.

The study design is a randomized control, double blind trial. Each patient will be assessed before, during, and after the trial by physical examination, blood tests and questionnaires. The patients will be randomized into research group (treated by ketamine and midazolam intravenously) or control group (treated intravenously via midazolam only).

sedative
ketamine
suicidal
arrhythmia
midazolam
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  • 19 Feb, 2024
Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients

This is a pilot study using cytotoxic T lymphocytes (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Gamma-capture system will be effective in decreasing specific viral load in patients with BK virus viremia and BK virus-associated symptoms post-allogeneic hematopoietic stem cell transplantation (HSCT), renal transplantation, and chemotherapy.

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  • 19 Feb, 2024
Clinical Study Relating to Patients Undergoing Medial Femoral Patellar Ligament Reconstruction

The objective of the present study will be to evaluate the clinical patellofemoral joint function (primary endpoint) and radiographically the patellofemoral arthritic degeneration (secondary endpoint) of of MPFL reconstruction with fascia lata allograft at a minimum follow-up of 2, 5 and 10 years in a group of 25 patients.

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  • 19 Feb, 2024
Tolerability Safety Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects

This is a randomized, double-blind, placebo-controlled, phase I clinical study to evaluate the tolerability, safety, pharmacokinetic profile and immunogenicity of JS016 (anti-SARS-CoV-2 monoclonal antibody) injection in Chinese healthy subjects after intravenous infusion of single dose.Eligible patients will be injection JS016 (anti-SARS-CoV-2 monoclonal antibody)

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  • 19 Feb, 2024