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Found 1304 clinical trials
Early Detection of Familial Hypercholesterolemia in Children

Heterozigous FH is an underdiagnosed disease in the paediatric population. Its early detection, would allow us to initiate lifestyle therapeutical changes and early pharmacological therapy if necessary. This is a key fact to reduce atherosclerosis progression and cardiovascular risk in adulthood. Moreover, it will allow, detecting the first and second …

nephrotic syndrome
hypercholesterolemia
early detection
diabetes
genetic disorder
  • 0 views
  • 19 Feb, 2024
Obstructive Sleep Apnea Syndrome In Patients Treated For Cancer Of The Upper Aerodigestive Tract

Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract. The patient follows a usual course of care including, at the end of the treatment of his cancer of the upper aerodigestive tract, screening …

cancer
lymph node metastases
metastasis
dental caries
primary cancer
  • 0 views
  • 19 Feb, 2024
Change of NLRP3 Inflammasome Expression Level Symptoms and Functional Status in HFpEF Patients Treated With ARNI

Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction(HFpEF). But there is no study reported the relationship between NLRP3 inflammasome and HFpEF. In this study, investigators propose a scientific hypothesis that the expression of NLRP3 inflammasome is elevated in patients with HFpEF, and the level …

diastolic dysfunction
ntprobnp
n-terminal pro-bnp
sacubitril
valsartan
  • 0 views
  • 19 Feb, 2024
Amplatzer Piccolo Occluder Japan Post-marketing Database Surveillance

The purpose of this post-marketing clinical use database surveillance is to observe the frequency, type, and degree of adverse device effects and adverse events in order to assure the safety of the medical device, and to collect safety and efficacy information for evaluating the results of its clinical use.

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  • 19 Feb, 2024
Prospective Analysis of the Feasibility of the PASCAL Spacer Technology for Transcatheter Mitral Valve Repair in an All-comers Cohort

To identify changes on mitral valve morphology and functionality by the application of the PascalTM in MR.

mitral valve repair
  • 0 views
  • 19 Feb, 2024
Sleep-disordered Breathing in Infants With Myelomeningocele

This study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs. postnatal surgery, and to examine the link between sleep-disordered breathing and neurodevelopment.

spina bifida
sleep-disordered breathing
polysomnography
  • 0 views
  • 19 Feb, 2024
Mechanisms of Hypoglycemia in Patients Without Diabetes

The goal of this study is to identify physiologic and molecular mechanisms that underlie hypoglycemia in the absence of diabetes (or medications that can cause hypoglycemia) and to investigate potential genetic and microbiome differences which contribute to hypoglycemia. We will test the hypothesis that hypoglycemia in the absence of diabetes …

neuroglycopenia
bariatric surgery
continuous glucose monitoring
hypoglycemia
diabetes
  • 0 views
  • 19 Feb, 2024
Evaluating Cascade Communication Methods

Hereditary cancer programs face challenges with respect to effective communication of genetic test results within families and uptake of genetic testing by relatives. This study aims to determine if a "disclosure toolkit" provided to the index participant (carrier of cancer risk gene mutation) contributes to sharing genetic test results with …

cancer
genetic test
hereditary cancer
genetic testing
  • 0 views
  • 19 Feb, 2024
Correlation Between Oxidative Stress Status and COVID-19 Severity

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system …

multiple organ failure
elisa
  • 0 views
  • 19 Feb, 2024
Comparison of Ultrasound-determined and Intraoperative #Enzian-classification in Patients With Deep Endometriosis

The Enzian classification, which was developed in order to describe deep endometriotic (DE) lesions, is determined intraoperatively by the surgeon. Transvaginal ultrasound (TVS) examination is considered as the first-line imaging technique for endometriosis. The aim of this study is to compare the assessment of presence and severity grade of endometriotic …

deep endometriosis
endometriosis
transvaginal ultrasound
  • 0 views
  • 19 Feb, 2024