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Found 1304 clinical trials
Serial Tumour Biopsies and Blood Biomarkers in Melanoma

The study will be open to NHS patients aged 16 and over, who have been diagnosed with advanced melanoma, and who will be receiving treatment for their disease as part of their routine care.

cancer
advanced melanoma
cancer treatment
metastatic melanoma
metastatic malignant melanoma
  • 0 views
  • 19 Feb, 2024
Detection of Metabolite Biomarkers for the Early Diagnosis and Prognosis of Cow's Milk Allergy in Children

The samples will be analyzed using a technique called metabolomics to identify biomarker candidates with diagnostic and/or prognostic potential. Additionally, microbiome analysis will be performed to map the microbiome of all groups.

early diagnosis
allergy in children
milk allergy
food allergy
  • 0 views
  • 19 Feb, 2024
Kinematic Versus Mechanical Alignment in Total Knee Replacement

This prospective controlled double-blind randomized study compares kinematic and mechanical alignment in TKA (Total knee arthroplasty). A total of 120 patients will be included and the surgery will be performed using CT based 3D printed PSI(Patient Specific Instruments) Cutting guides.

total knee replacement
osteoarthritis
  • 0 views
  • 19 Feb, 2024
Role of Children in Transmission of COVID-19 to Immunocompromised Patients

Additionally, participants will be contacted by telephone at 1 year for follow-up.

cancer
covid-19
lymphoma
stem cell transplantation
leukemia
  • 0 views
  • 19 Feb, 2024
Epidemiological Study of the Microbiota in Critically Ill Children (n=100) From 1 to 16 Years Compared With Healthy Controls (n=50) and Its Relationship With Clinical Complications and Inflammatory Biomarkers

Clinical parameters and rectal, fecal, blood and respiratory samples will be collected at admission and at pediatric intensive care units discharge. The microbiota and inflammation biomarkers and metabolomic will be analyzed.

  • 0 views
  • 19 Feb, 2024
Is COVID-19 Transmitted Through Human Milk? Implications for Breastfeeding and Human Milk Banking-Study 1a

This study seeks to address this public health issue. Breastmilk will be collected from mothers positive for COVID-19. Samples will be analyzed for the COVID-19 virus specific nucleic acid and antibody in real-time and results will be immediately disseminated to relevant organizations to inform local, national and international guidelines surrounding …

covid-19
  • 0 views
  • 19 Feb, 2024
Impact of Sinus Surgery on Individuals With Cystic Fibrosis

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS).

sinus surgery
sweat chloride
medical therapy
genetic testing
sweat chloride test
  • 0 views
  • 19 Feb, 2024
Characterization of the Clinical-epidemiological Profile of Patients With SMA5q Types II and III: Observational Study

This study aims to characterize the clinical-epidemiological profile and baseline characteristics of patients with spinal muscular atrophy (SMA) 5q types II and III in follow-up at the Brazilian Unified Public Health System (SUS). The study data will be based on patients medical records from several Brazilian public hospitals, which will …

muscle atrophy
nusinersen
spinal muscular atrophy
atrophy
  • 0 views
  • 19 Feb, 2024
Streamlining the Efficiency of PrEP Implementation

This is a pilot facility-based direct-to-pharmacy PrEP refill delivery to streamline care pathway in Kenyan public health HIV facilities implementing PrEP. Data on up to 500 PrEP users will be evaluated to understand delivery efficiency and in-depth interview with users and delivery key informants will be conducted to identify barriers …

blood draw
hiv test
  • 0 views
  • 19 Feb, 2024
Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors

Data Analysis: would be performed using the Statistical Package for Social Sciences (SPSS) software version 21.0. Numerical data would be expressed as mean standard deviation (SD).

myocardial infarction
apob
hypertension
heart disease
atherosclerosis
  • 0 views
  • 19 Feb, 2024