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Found 19 clinical trials
Featured trial
l Investigation of Robotic-assisted TKA (RA-TKA) With Skywalker and Evolution Medial Pivot Knee (eMP Knee) (123)

This is a prospective trial that attempts to develop evidence on the safety and performance of RA-TKA (Robotic-assisted total knee arthroplasty) with Skywalker and eMP (Evolution Medial Pivot) knee. Moreover to evaluate performance of eMP patients with Skywalker (in comparison to eMP with conventional instrumentations and non-MP TKAs)

Accepts healthy volunteers
Online studies
  • 0 views
  • 14 May, 2025
  • Online study
Comparison of Tofacitinib and Methotrexate in Takayasu's Arteritis

The aim of this study is to evaluate and compare the efficacy and safety of tofacitinib and methotrexate based on prednisone therapy in patients with Takayasu arteritis

  • 0 views
  • 19 Feb, 2024
Efficacy and Safety of Romiplostim Versus Eltrombopag in the Treatment of Thrombocytopenia in Patients With Wiskott-Aldrich Syndrome

This is a prospective, open-label, randomized, two-arm clinical trial conducted to evaluate the safety and efficacy of romiplostim in comparison with eltrombopag in the treatment of thrombocytopenia in patients with Wiskott-Aldrich syndrome

platelet count
wiskott-aldrich syndrome
eltrombopag
thrombocytopenia
romiplostim
  • 0 views
  • 19 Feb, 2024
Abatacept in Individuals Who aRe Considered At Risk of Developing Inflammatory Arthritis

Phase II, single-centre, open label, two parallel arm cohort randomised controlled trial (RCT) testing abatacept in a population of anti-CCP Ab positive individuals at moderate to high risk of developing IA according to a published risk score, already followed in the observational study 'CCP: Next Generation'

abatacept therapy
stiffness
arthritis
tenderness
abatacept
  • 0 views
  • 19 Feb, 2024
A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)

Primary Objective: To describe the pharmacokinetic (PK) profile of sarilumab in patients aged 1-17 years with Systemic Juvenile Idiopathic Arthritis (sJIA) in order to identify the dose and regimen for adequate treatment of this population. Secondary Objective: To describe the pharmacodynamics (PD) profile, the efficacy, and the long term safety …

rheumatic diseases
glucocorticoids
antirheumatic
fever
disease modifying antirheumatic drugs
  • 0 views
  • 19 Feb, 2024
  • 30 locations
An Open-label Ascending Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Polyarticular-course Juvenile Idiopathic Arthritis (pcJIA)

Primary Objective: To describe the pharmacokinetic (PK) profile of sarilumab in patients aged 2-17 years with Polyarticular-course Juvenile Idiopathic Arthritis (pcJIA) in order to identify the dose and regimen for adequate treatment of this population Secondary Objective: To describe the pharmacodynamic (PD) profile, the efficacy and the long-term safety of …

sarilumab
antirheumatic
disease modifying antirheumatic drugs
arthritis
rheumatoid factor
  • 0 views
  • 19 Feb, 2024
  • 33 locations
The Anti-inflammatory Effects of Hark ny Medicinal Water

The study aims to provide evidence on the effectiveness of Harkny medicinal water in psoriatic and rheumatoid arthritis patients using subjective and objective methods. It is a cross-over study, so first half of patients will receive medicinal water, the other half will receive tap water treatment, and after 6 months …

renal disease
skin lesion
arthritis
psoriasis vulgaris
psoriasis
  • 0 views
  • 19 Feb, 2024
Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions  

In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body. In recent publications, the role of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Macrophage Inflammatory Protein (MIP)-1α and Interleukin (IL)-1β on chronic inflammatory diseases has been investigated. …

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  • 08 May, 2025
TPM Regimen (Thalidomide Prednisone and Methotrexate) in LGLL

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disease, with LGL infiltration in peripheral blood and bone marrow, hepatosplenomegaly, and cytopenia. Both T-LGLL and CLPD-NK are indolent disease and share similar biology and clinical course, and treated under the same strategy. So the investigators put them together as LGLL. The …

lymphoproliferative disorder
t-cell large granular lymphocytic leukemia
prednisone
methotrexate
lymphoid leukemia
  • 0 views
  • 19 Feb, 2024
Comparative Effectiveness of Targeted Therapy in RA Patients

The objective of a multicenter prospective observational study is to compare effectiveness and safety of biologic disease-modifying antirheumatic drugs and small molecular inhibitors in patients with moderately to severely active rheumatoid arthritis patients who have had an inadequate response or intolerace to methotrexate.

baricitinib
tocilizumab
arthritis
tofacitinib
methotrexate
  • 0 views
  • 19 Feb, 2024