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Found 13 clinical trials
Featured trial
A5418 Study of Tecovirimat for Human Monkeypox Virus (STOMP)  

Participants with severe disease, significant skin conditions, participants with severe immune suppression will receive open-label tecovirimat. Participants who are pregnant or breastfeeding will receive open-label tecovirimat after discussion of the potential risks and benefits.

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  • 19 Feb, 2024
  • 1 location
Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP) (Lympho-PTT)

The aim is to highlight their contribution to the initial pathogenic process, their evolution under treatment, and also their involvement in patients who are refractory to immunosuppressive therapies and during relapses. The aim of this project is to identify early phenotypic or functional parameters that are predictive of relapse and …

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  • 18 May, 2025
Precision Guided Tacrolimus Dosing in Pediatric Heart Transplant

Immunosuppressive therapy is required to prevent organ rejection, however, dosing of immunosuppressive agents is complicated by patient-specific differences impacting the body's absorption and elimination of these agents.

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  • 19 Feb, 2024
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function

Additionally, Everolimus is known to induce tolerance in transplant recipients. Tolerant patients do not require immunosuppression to accept transplant organs. Tacrolimus is a widely used in liver transplant recipients for immunosuppression, however it is associated with nephrotoxicity.

mycophenolic acid
hepatitis b
renal impairment
nephropathy
everolimus
  • 0 views
  • 19 Feb, 2024
Restrictive Use of Dexamethasone in Glioblastoma

However, steroids are also linked to a multitude of adverse side effects that may affect survival of GBM patients such as major immunosuppression. The use of steroids during radiotherapy is associated with reduced overall- and progression-free survival and has been identified as an independent poor prognostic factor.

neurologic symptoms
immunosuppression
glioblastoma multiforme
dexamethasone
  • 0 views
  • 19 Feb, 2024
Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma

After tumor hypoxia, high expression of VEGF will induce tumor cells to express programmed cell death protein-1 (PD-1), which further leads to immune escape. Targeted drugs against angiogenesis can relieve immunosuppression to a certain extent, and theoretically have a synergistic effect with anti-PD-1 immunotherapy. The innovation of this study is …

tumor angiogenesis
head and neck squamous cell carcinoma
hypoxia
tumor growth
camrelizumab
  • 0 views
  • 19 Feb, 2024
Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work in treating patients with pneumonitis that does not respond to steroid treatment. Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow …

corticosteroid therapy
systemic therapy
oophorectomy
bilateral oophorectomy
urine test
  • 0 views
  • 19 Feb, 2024
TPM Regimen (Thalidomide Prednisone and Methotrexate) in LGLL

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disease, with LGL infiltration in peripheral blood and bone marrow, hepatosplenomegaly, and cytopenia. Both T-LGLL and CLPD-NK are indolent disease and share similar biology and clinical course, and treated under the same strategy. So the investigators put them together as LGLL. The …

prednisone
hepatosplenomegaly
clpd-nk
leukemia
cytopenia
  • 0 views
  • 19 Feb, 2024
Low Dose Ruxolitinib in Combination With Methylprednisolone

This study is to determine the efficacy and safety of combined Low dose Ruxolitinib With Methylprednisone as Initial Therapy for the aGVHD(acute graft-versus-host disease )

acute graft versus host disease
regenerating islet derived protein 3
allogeneic hematopoietic stem cell transplant
cancer
tumorigenicity
  • 0 views
  • 19 Feb, 2024
Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal …

rapid plasma reagin measurement
leukemia
forced expiratory volume
pulmonary function test
acute myeloid leukemia
  • 0 views
  • 19 Feb, 2024