Torento, Canada Clinical Trials

A listing of Torento, Canada clinical trials actively recruiting patients volunteers.

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Found 66 clinical trials
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical events committee (CEC)-adjudicated morbidity or mortality (M/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.

macitentan 10 mg
macitentan
hypertension
left ventricular end-diastolic pressure
atrial septal defect
University Health Network - Toronto General Hospital
 (0.5 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +210 other locations
מחקר להערכת הבטיחות, היעילות והאימונוגניות של חיסון mRNA לאקנה במבוגרים עם אקנה בינונית עד חמורה  

מטרת הניסוי היא להעריך את הבטיחות, היעילות והאימונוגניות של עד 3 זריקות תוך שריריות של חיסון mRNA לאקנה בעד שלוש רמות מינון במשתתפים בוגרים בגילאי 18 עד 45 עם אקנה בינונית עד חמורה.

replacement therapy
enzyme assay
platelet count
gaucher disease
deficiency
Investigational Site Number 1240001
 (1.2 away)
  • 0 views
  • 10 Sep, 2025
  • +21 other locations
A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

Primary Objective: To determine the effect of venglustat on the rate of total kidney volume (TKV) growth (Stage and estimated glomerular filtration rate (eGFR) decline in patients at risk of rapidly progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD) (Stage 2). Secondary Objectives: To determine the effect of venglustat on the …

antihypertensive therapy
human chorionic gonadotropin
autosomal dominant
ophthalmological examination
urine osmolality
Investigational Site Number 1240001
 (1.2 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +80 other locations
Safety and Efficacy of Eliglustat With or Without Imiglucerase in Pediatric Patients With Gaucher Disease (GD) Type 1 and Type 3

Primary Objective: Evaluate the safety and pharmacokinetics of eliglustat in pediatric patients (2 to <18 years old). Secondary Objective: Evaluate the efficacy of eliglustat and quality of life in pediatric patients (2 to <18 years old).

replacement therapy
enzyme assay
platelet count
gaucher disease
deficiency
Investigational Site Number 1240001
 (0.3 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +22 other locations
Benefits of Exercise in Alzheimer's Disease

Exercise has been shown to be beneficial for the brain. The investigators would like to test this specifically for those diagnosed with Alzheimer's disease. This study will involve 30 randomized patients to take part in the out-patient exercise program and 30 patients to continue with their regular activities over a …

behavioral symptoms
cognitive assessment
neuropsychological test
alzheimer's disease
dementia
Toronto Western Hospital, WW5-449
 (1.1 away) Contact site
  • 4 views
  • 19 Feb, 2024
  • 1 location
Precision Orthodontics: A Comparison of Custom vs Traditional Bracket Treatment Efficiency

This investigational testing aims to target multiple investigations sites to examine treatment efficiency metrics using a completely digital and patient-specific bracket treatment system for the correction of malocclusions.

eruption
Orthodontics at Don Mills
 (7.0 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +2 other locations
Blood-Brain-Barrier Disruption With Cerezyme in Patient's With Parkinson's Disease

This clinical trial focus on the delivery of Cerezyme in Parkinson's Disease (PD) patients using MR-guided focused ultrasound (MRgFUS) induced opening of the blood-brain barrier (BBB).

parkinson's disease
Sunnybrook Health Sciences Centre
 (4.7 away) Contact site
  • 16 views
  • 19 Feb, 2024
  • 1 location
Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients With Chest-wall and Locally-Advanced Breast Cancer

The objective of this study is to demonstrate the feasibility of novel MRI-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam radiotherapy delivered using a LINAC (linear accelerator) radiation therapy device.

advanced breast cancer
carcinoma
breast cancer staging
potassium
Sunnybrook Health Sciences Centre
 (4.7 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • 1 location
First in Human Study of M6223 in Participants With Metastatic or Locally Advanced Solid Unresectable Tumors

The main purpose of this study is to determine the safety, tolerability, pharmacokinetics (PK), immunogenicity and (if observed) the maximum tolerated dose (MTD) of M6223 as a single agent (Part 1A) and of M6223 combined with bintrafusp alfa (Part 1B) in participants with metastatic or locally advanced solid unresectable tumors.

Sarah Cannon Research Institute
 (647.1 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +3 other locations
Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients With Head and Neck Cancer

The objective of this study is to demonstrate the feasibility of novel MRI-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam radiotherapy delivered using a LINAC (linear accelerator) radiation therapy device.

carcinoma
dental caries
chemoradiotherapy
neck cancer
lymphadenopathy
Gregory J Czarnota
 (4.7 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • 1 location