Neoplasms Clinical Trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 8031 clinical trials
BCMA-Targeted CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

This is a single arm study to evaluate the efficacy and safety of BCMA-targeted CAR-T cells therapy for patients with relapsed/refractory Multiple Myeloma.

multiple myeloma
cellular therapy
stem cell transplantation
remission
bcma
  • 0 views
  • 24 Nov, 2025
  • 1 location
LYT-100 in Healthy Volunteers and BCRL

Part 1 is a multiple ascending dose trial in healthy volunteers (HV) of LYT-100 to determine safety, tolerability, and pharmacokinetic (PK) profile under fed conditions. Part 2 is a single dose safety, tolerability, and PK trial in HV of LYT-100 under fasted conditions. Part 3 is a trial of up …

adjuvant
secondary lymphedema
HER2
carcinoma
cancer
  • 0 views
  • 19 Feb, 2024
  • 1 location
Concurrent Chemoradiotherapy After Endoscopic Resection for Stage I Esophageal Carcinoma

This is a prospective single-arm study of endoscopic resection (ER) following concurrent chemoradiotherapy for stage I esophageal squamous cell carcinoma, to find if the treatment combination is useful by assessing its safety and efficacy.

chemoradiotherapy
primary lesion
lymph node metastases
endoscopic ultrasound
esophageal squamous cell carcinoma
  • 0 views
  • 19 Feb, 2024
  • 1 location
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

infertility
stem cell transplantation
testicular
autograft
anesthesia
  • 0 views
  • 19 Feb, 2024
  • 1 location
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function

Secondary Aims Compare the efficacy of Everolimus plus Mycophenolate Mofetil versus Tacrolimus plus Mycophenolate Mofetil therapy as measured by the following: Biopsy-confirmed acute rejection Hyperlipidemia Proteinuria % regulatory T-cells in circulation NODAT [New Onset Diabetes mellitus After Transplant], hypertension and malignancy Tolerance measured by gene profiling at year 1, 2 …

diabetes
nephropathy
renal impairment
hepatitis c
organ rejection
  • 0 views
  • 19 Feb, 2024
  • 1 location
Improving Survivorship Care for Older Adults After Chemotherapy

The researchers want to find out if older adults receiving a survivorship care plan followed by a geriatric assessment visit improves quality of life and satisfaction with care compared to receiving only a survivorship care plan for older adults who have completed chemotherapy for cancer treatment.

  • 0 views
  • 19 Feb, 2024
  • 1 location
the Efficacy and Safety of 5-HT3 Receptor Antagonist Dexamethasone or Megestrol Acetate Dispersible Tablets in the Control of Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy

To compare the efficacy and safety of megestrol acetate dispersible tablets combined with 5-HT3 receptor antagonist and dexamethasone triple antiemetic regimen and 5-HT3 receptor antagonist and dexamethasone combined antiemetic regimen in the control of CINV induced by hyperemetic chemotherapy.

emetic
antiemetic
megestrol
nausea and vomiting
emetics
  • 0 views
  • 19 Feb, 2024
  • 1 location
Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts the body and is PD-L1-negative. The names of the study interventions involved in this study are: Sacituzumab govitecan (IMMU-132) Pembrolizumab (Keytruda; MK-3475)

stage iv breast cancer
brain metastases
progesterone
liver metastasis
periodic abstinence
  • 8 views
  • 19 Feb, 2024
  • 1 location
CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

Drugs used in chemotherapy, such as CPX-351, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

treatment related aml
myelodysplasia
aml
myeloid leukemia
myelodysplastic syndrome
  • 0 views
  • 19 Feb, 2024
  • 1 location
Ibrutinib + Venetoclax in Untreated WM

This study evaluates the safety and efficacy of Ibrutinib combined with Venetoclax (IVEN) in the treatment of adults diagnosed with Waldenstrom's macroglobulinemia (WM) cancer with a specific MYD88 gene mutation. This research study involves an experimental drug combination of targeted therapies.

growth factor
ibrutinib
neutrophil count
absolute neutrophil count
bone marrow biopsy
  • 0 views
  • 19 Feb, 2024
  • 2 locations